3.A.1.135.6
Two component multidrug efflux pump with the 6 TMS membrane domain preceding the ATPase domain in both proteins. Confers resistance to erythromycin and tetracycline and catalyzes export of Hoechst 33342 (Moodley et al. 2014). Expression is induced by the presence of erythromycin.
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| Accession Number: | E8MFM4 |
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| Protein Name: | Putative ABC transporter permease component |
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| Length: | 623 |
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| Molecular Weight: | 67961.00 |
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| Species: | Bifidobacterium longum subsp. longum (strain ATCC 15707 / DSM 20219 / JCM 1217 / NCTC 11818 / E194b) [565042] |
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| Number of TMSs: | 6 |
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| Substrate |
2'-(4-ethoxyphenyl)-5-(4-methylpiperazin-1-yl)-2,5'-bibenzimidazole, tetracycline, erythromycin A |
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1: MLRIMKYLSK AEIGQMLIAL VTIVGQVYFD LKLPDYMSDI TTLVETPGSH MKDIWIAGGK
61: MLLISLGSAA CAIITGYIAA RVAASFTQRL RSLEFRKVES FGPAEMSKFS TASLITRSTN
121: DVTQVQMFIT MGLQLIVKSP IMAVWAVCKI AGEGFEWTLA TGIAVVILLA AIVIMMAMVM
181: PKFKAMQALT DNINLVAREN LTGLRVVRAY NAEDYQEAKF TKANKDLTDT QLFTNRVMAF
241: MMPLMNTIMN GLMLAVYWIG TYLIDAAGLK DKLTVFSNMV VFSNYSVQVI MSFLLMSMVF
301: VLWPRADVSA QRIMEVLDTE PIVENGTKTA ADVAKTGQRG TVEFRNVSFT YPDSREAMLE
361: GINFTAEQGQ TVAFIGSTGS GKSSLINLVP RFYDTSQGQV LVDGVDVRDY DLKALRDKIG
421: YVPQQSVLFK GTVASNVSYG DQPGDPAEVE MADTSTPAGR KREAALIAAG EAAEGADIPA
481: EQLNRVKAAA DVAQASEFVA RMDGGYSAAI AQGGSNVSGG QKQRLSIARA VYRHPEILIF
541: DDSFSALDFK TDREVRDALA REAKDSTKLI VAQRIGTIMN ADRIVVLDDG KVVGQGTHKE
601: LLDNCDVYRQ IAESQLSQSE LTA