1.A.17.4.13
Tmc1/Tmc2a or Tmc2b/protocadherin 15a (Pcdh15a). The complex is part of a mechanotransduction system (Maeda et al. 2014). Its trafficing to the plasma membrane depends on the transmembrane O-methyltransferase (TOMT/LRTOMT; 259 aas, 1 N-terminal TMS) (Erickson et al. 2017). Water motion is dependent on this complex (Chou et al. 2017). The role of another protein, Tmie (see TC# 8.A.115), in sensory hair cells is to target and stabilize the Tmc channel subunits to the stereocilia, the site of mechano-electrical transduction (Pacentine and Nicolson 2019). Tmc proteins 1, 2a and 2b are essential for zebrafish hearing although Tmc1 is not, probably because they can (at least partially) substitute for each other (Chen et al. 2020). There are two distinct cell types in inner ear hairs, an upper layer of teardrop shaped cells that rely on Tmc2a, and a lower layer of gourd shaped cells that rely on Tmc1/2b (Smith et al. 2020). Tmc reliance in the ear is dependent on the organ, subtype of hair cell, position within the ear, and axis of best sensitivity (Zhu et al. 2020).
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| Accession Number: | F1QFU0 |
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| Protein Name: | Transmembrane channel-like protein 1 |
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| Length: | 935 |
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| Molecular Weight: | 107497.00 |
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| Species: | Danio rerio (Zebrafish) [7955] |
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| Number of TMSs: | 10 |
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| Location1 / Topology2 / Orientation3: |
Cell membrane1 / Multi-pass membrane protein2 |
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| Substrate |
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1: MPRHKLIASE SDVSIEVDEG KDKESCVYYV EVEENCERGK IKQASRDGKR RRERNGETRR
61: KASEKRTNEG ESKKAEKKHE KGHRTARKAG EKHGKRQRRK NAGEEDAEDK SSKEKKNMKN
121: EKNKTLKLEE EKEKDVRKKK RKHVKNEEDE TNHEKTKQHL KEEKRRKKRK KPETTSESES
181: KSESESASES ESKNSPAVGV LGSLTPEELE NLKEAVEERK KLITQLKGKP WPMRRKLVVL
241: RESQEFVEKY EGALGKGKGR KLYAYKVMMM KKWMKFQRDF ENFKTACIPW EMKIKEIESH
301: FGSSVASYFI FLRWMYGINM ILFGLTFGLV MVPEALMGKP YGSLPRKTVP REEEASAMNF
361: AVLWDFGGYA KYSVLFYGYY NSQRAIGWLK FRMPLSYFLV GVGTVAYSYM VVIRTMARNA
421: NEEGGGDDTS FNFSWKTFTS WDYLIGNPET ADNKFASITT SFKEAIVEEQ ESRKDDNIHL
481: TRFLRVLANF LVLCCLAGSG YLIYFVVRRS QKFALEGLEN YGWWERNEVN MVMSLLGMFC
541: PMLFDVISTL ENYHPRIALQ WQLGRIFALF LGNLYTFIIA LMDAIQLKRA EEEIVKKNMT
601: IWQANLYNGT VPDNSTAPPL TVHPADVPRG PCWETMVGQE FVRLIISDTM TTYITLLIGD
661: FMRAVLVRFL NNCWCWDLEY GFPSYSEFDV SGNVLGLIFN QGMIWMGAFY APCLPALNLL
721: RLHVSMYLQC WAVMCCNVPQ ERVFKASGSN NFYMAMLLVI LFLSTLPAIY TIVSIPPSFD
781: CGPFSGKPRM FDVIQETLET DFPAWFSKVF SYASNPGLVL PFLLLLVLAI YYLQSTSKTY
841: KRVNMELKKK LQAQNEENKK KNKLAALKAA SDLEQARKAG EQRRNSISDL GVNEENPESH
901: VSSSHTSRPP ASRGHTSSGH LPGHPQQPQK NSKKR