1.A.17.4.13
Tmc1/Tmc2a or Tmc2b/protocadherin 15a (Pcdh15a). The complex is part of a mechanotransduction system (Maeda et al. 2014). Its trafficing to the plasma membrane depends on the transmembrane O-methyltransferase (TOMT/LRTOMT; 259 aas, 1 N-terminal TMS) (Erickson et al. 2017). Water motion is dependent on this complex (Chou et al. 2017). The role of another protein, Tmie (see TC# 8.A.115), in sensory hair cells is to target and stabilize the Tmc channel subunits to the stereocilia, the site of mechano-electrical transduction (Pacentine and Nicolson 2019). Tmc proteins 1, 2a and 2b are essential for zebrafish hearing although Tmc1 is not, probably because they can (at least partially) substitute for each other (Chen et al. 2020). There are two distinct cell types in inner ear hairs, an upper layer of teardrop shaped cells that rely on Tmc2a, and a lower layer of gourd shaped cells that rely on Tmc1/2b (Smith et al. 2020). Tmc reliance in the ear is dependent on the organ, subtype of hair cell, position within the ear, and axis of best sensitivity (Zhu et al. 2020).
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| Accession Number: | F1QZE9 |
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| Protein Name: | Transmembrane channel-like protein |
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| Length: | 892 |
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| Molecular Weight: | 102045.00 |
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| Species: | Danio rerio (Zebrafish) [7955] |
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| Number of TMSs: | 10 |
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| Location1 / Topology2 / Orientation3: |
Membrane1 / Multi-pass membrane protein2 |
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| Substrate |
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1: MCVLQLGWKW MQNLIVEVMW TQKEEQKAGI NQNLRREEGK PNQQTVWRRA KKRRMNRRAR
61: GEAGGRSKKM RMRVRKNRRE EERKLSIPGR EQQRKTSQRR RSPSSCSSSS DNNSDDESMS
121: EGEMARLKEE VEEKKKLIAT LRNKPWRMKR RLKCLKEAQE FVEKFEGALG KGKGRRLYAF
181: KVMMTKKLIK FNRDFENFKT ACIPWESRIK EVESHFGSSV ASYFIFLRWM YGLNLVLFGF
241: MFGLVVIPEL LMGIPYGSIP RKTVPREEQD SAMDFSVLFE FGGYCKYSIL FYGFYNNQRT
301: IGFLQFRLPL SYLLVGVGIF GYSLMVVIRT MARNANEGGD GGDEGNFTFC WKLFTSWDYL
361: IGNPETADNK FASTTTSFKE SIVDEQENLK DENIHLRRFL RLLANVLILC CLAGSGYLIY
421: AVVKRSQDFA KRDRNELTWL QKNEVEIVMS LLGLVCPPLF EAIAELEDYH PRIALKWQLG
481: RIFALFLGNL YTFLFALFDE VNGKLENEKQ IKNQTVWALK EYYANYTLQY NITENIPPPN
541: IAPADVIRGP CWETEVGIEF VKLTVSDIQV TYLTILIGDF LRALIVRFLN YCWCWDLEAG
601: FPSYAEFDIS GNVLGLIFNQ GMIWMGAFYA PGLVGINVLR LLSSMYYQCW AVMACNVPHE
661: RVFKASRSNN FYMGLLLLVL FLSLMPVIYS IMTLPPSFDC GPFSGKDKMY DVITETIDKD
721: LPPFMADIFS YASNPGLIIS VVLLMVWLAI YYLNAVSKAY QNSNLELKRK MQMQRDEEKN
781: RRNNKDSTNQ VMKDLEDLLP NKSLIPPPSV EETEKPAEQP SKSSKVTGKP GAAASGKGVH
841: VQKDVSLAAA NPRAPVTRAP GPRQPGPLPG NPRGPPPGQG MGRGRGGPPP RR