1.G.22.1.1
The gO or gL glycoprotein fusogen of 278 aas and 3 TMSs, 1 N-terminal and 2 near the C-terminus (Feng and Jia 2016). The heterodimer glycoprotein H (742 aas; 2 TMSs, N- and C-terminal)-glycoprotein
L is required for the fusion of viral and plasma membranes leading to
virus entry into the host cell. Membrane fusion is mediated by the
fusion machinery composed at least of gB (907 aas; 3 TMSs, 1 N-terminal and 2 near the C-terminus; similar to gB of 1.G.10.1.1) and the heterodimer gH/gL.
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| Accession Number: | F5HCH8 |
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| Protein Name: | Envelope glycoprotein L |
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| Length: | 278 |
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| Molecular Weight: | 30815.00 |
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| Species: | Human cytomegalovirus (strain Merlin) (HHV-5) [295027] |
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| Number of TMSs: | 3 |
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| Location1 / Topology2 / Orientation3: |
Virion membrane1 / Peripheral membrane protein2 / Extracellular side3 |
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| Substrate |
molecule |
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1: MCRRPDCGFS FSPGPVILLW CCLLLPIVSS AAVSVAPTAA EKVPAECPEL TRRCLLGEVF
61: EGDKYESWLR PLVNVTGRDG PLSQLIRYRP VTPEAANSVL LDEAFLDTLA LLYNNPDQLR
121: ALLTLLSSDT APRWMTVMRG YSECGDGSPA VYTCVDDLCR GYDLTRLSYG RSIFTEHVLG
181: FELVPPSLFN VVVAIRNEAT RTNRAVRLPV STAAAPEGIT LFYGLYNAVK EFCLRHQLDP
241: PLLRHLDKYY AGLPPELKQT RVNLPAHSRY GPQAVDAR