3.A.1.21.3
IrtAB of 908 aas and 6 TMSs in a 2 + 2 + 2 TMS arrangement, and 579 aas, also with 6 TMSs in a 2 + 2 + 2 TMS arrangement, respectively. Together they form an ATC transporter with two membrane domains and two ATPase domains. They differ from 3.A.1.21.2, being about 70% idential with respect to both the two subunits. See IrtAB with TC# 3.A.1.21.2 for details about this transport system. It may function together with cMBT for the import of iron-bound carboxymycobactin (cMBT) (Shankar and Akhter 2025).
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| Accession Number: | G7CBF5 |
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| Protein Name: | Mycobactin import ATP-binding/permease protein IrtA |
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| Length: | 908 |
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| Molecular Weight: | 98141.00 |
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| Species: | Mycolicibacterium thermoresistibile (strain ATCC 19527 / DSM 44167 / CIP 105390 / JCM 6362 / NCTC 10409 / 316) (Mycobacterium thermoresistibile) [1078020] |
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| Number of TMSs: | 6 |
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| Location1 / Topology2 / Orientation3: |
Cell inner membrane1 / Multi-pass membrane protein2 |
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| Substrate |
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1: MARGFQGVML RGLGARDHQA TVVDKEYIAP HFVRVRLVSP TLFDEVIVEP TSWLRFWFPD
61: PDGSDTEFQR AYTITESDPE TGRFAVDMVL HEPAGPASTW ARTVEPGATI AVMSMGSRGF
121: SVPEDPEDRP VGYLLIGDSA STPAINGIIE VVPHDIPIEL YLEQHHDDDV LIPLAEHPRL
181: RVHRVSRDDA SSLAAALELR DWSNWYCWAG PEAGALKQVR TRLRDEFGFP KREVYAQAYW
241: TEGRAMGSSR GETSTPAKPA AKTAPAKAAA KPAAASGAGT PEHAAAPAAA TTGAPQAAPA
301: PGAAQPRTPV RGRWRAEAGS RLLAPLKKPL IVSGVLQALI TLIELAPFVL LVELARLLLG
361: GAEAERLWTL GLTAVSLIGL GAVLAAAMTL WLHRVDARFA HELRGRLLTK LSRLPLGWFT
421: RRGSASTKQL VQDDTLALHY LITHAIPDAV AAVVAPVAVL VYLFVADWRV ALVLFIPVLV
481: YLVLMSVMTI QSGSKIAQAP RWAERMGGEA GAFLEGQPVI RIFGGAAASR FRRRLDDYID
541: FLVSWQRPFV GKKTLMDLVT RPATFLWIIL VAGVPLVVTG RMDPVNLLPF LLLGTTFGAR
601: LLGIGYGLSG IQTGMLAARR IQTVLDEPEL VVRDRTGQAG TDHASGDQAR PGTVELDRVS
661: FEYRPGVPVI RDVTLTLRPG TVTALVGPSG SGKSTLAALV ARFHDVTQGA IRVDGRDIRT
721: LTADELYRRV GFVLQDAQLV HGSVAENIAL AEPDAGLERI RTAARDAQIH DRITRMPDGY
781: DSVLGAGSAL SGGERQRVTI ARAILADTPV LVLDEATAFA DPESEYLVQQ AINRLTRDRT
841: VLVIAHRLHT ITHADQIVVL DDGRIVEVGT HDELLAAGGR YRGLWDSGRY SSPDAGRPVS
901: ADAVEVGR