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2.A.63.1.4
Multicomponent Na+:H+ antiporter, MrpA-G (ShaA-G) (all components comprise a multi-component complex) (Kajiyama et al., 2007; Morino et al., 2008). The MrpA, MrpB, and MrpD subunits contain membrane-embedded and essential acidic residues (Kajiyama et al. 2009). Several residues important for Na+/H+ antiport activity, sodium exclusion, individual Mrp protein levels, or Mrp complex formation have been identified (Morino et al., 2010).

Accession Number:O05229
Protein Name:MrpD
Length:493
Molecular Weight:53477.00
Species:Bacillus subtilis [1423]
Number of TMSs:14
Location1 / Topology2 / Orientation3: Cell membrane1 / Multi-pass membrane protein2
Substrate sodium(1+), hydron

Cross database links:

RefSeq: NP_391041.3   
Entrez Gene ID: 938858   
Pfam: PF00361   
KEGG: bsu:BSU31630   

Gene Ontology

GO:0016021 C:integral to membrane
GO:0005886 C:plasma membrane
GO:0008137 F:NADH dehydrogenase (ubiquinone) activity
GO:0015386 F:potassium:hydrogen antiporter activity
GO:0042773 P:ATP synthesis coupled electron transport
GO:0015992 P:proton transport
GO:0006814 P:sodium ion transport

References (7)

[1] “Analysis of the Bacillus subtilis genome: cloning and nucleotide sequence of a 62 kb region between 275 degrees (rrnB) and 284 degrees (pai).”  Oudega B.et.al.   9274030
[2] “The complete genome sequence of the Gram-positive bacterium Bacillus subtilis.”  Kunst F.et.al.   9384377
[3] “Detecting and analyzing DNA sequencing errors: toward a higher quality of the Bacillus subtilis genome sequence.”  Medigue C.et.al.   10568751
[4] “From a consortium sequence to a unified sequence: the Bacillus subtilis 168 reference genome a decade later.”  Barbe V.et.al.   19383706
[5] “mrp, a multigene, multifunctional locus in Bacillus subtilis with roles in resistance to cholate and to Na+ and in pH homeostasis.”  Ito M.et.al.   10198001
[6] “Mrp-dependent Na(+)/H(+) antiporters of Bacillus exhibit characteristics that are unanticipated for completely secondary active transporters.”  Ito M.et.al.   11356194
[7] “Catalytic properties of Staphylococcus aureus and Bacillus members of the secondary cation/proton antiporter-3 (Mrp) family are revealed by an optimized assay in an Escherichia coli host.”  Swartz T.H.et.al.   17293423

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Predict TMSs (Predict number of transmembrane segments)
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FASTA formatted sequence 
1:	MNNFVILPIL IPLLSAILLI FMTKNLMLMR IFSTAASAIG IVISGILVQT VFTKGIQTLS 
61:	LGGWKAPYGI VLAADQFASL LVLTTAIIGL LVGLYSFRSV GEKRERSFYY SGVQFLLAGV 
121:	SGAFLTGDLF NMYVFFELLL IASYMLIVLG GTKIQLRESL KYIVFNIVSS ALFVIGVGFL 
181:	YAVTGTLNMA DLSVKISESG QTGLITVIGV LLLLVFGMKG GIFPLYFWLP GSYYAPPAAI 
241:	SALFGALLTK VGLYAITRVF TLIFIHDTAF THQLMIWLAA LTVIFGVIGS LAYSNVMKIV 
301:	IYNIITAVGV ILFGVAVHTP ASIQGAIYYL IHDMLIKGAL FMLAGTLIAL TGTASLHKMG 
361:	GLIKRYPVLG WMFFISAISL AGIPPLSGFV GKFKIAEGGF AEGEFTISML ILLSSLLVLY 
421:	SVLRIFIHAF WGEEKETPKP NHRTAKGLLY PAAIFLLLSL LFGLGTEWVS PYVDQAAETL 
481:	LNPEKYIEAV LKE