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2.A.63.1.4
Multicomponent Na+:H+ antiporter, MrpA-G (ShaA-G) (all components comprise a multi-component complex) (Kajiyama et al., 2007; Morino et al., 2008). The MrpA, MrpB, and MrpD subunits contain membrane-embedded and essential acidic residues (Kajiyama et al. 2009). Several residues important for Na+/H+ antiport activity, sodium exclusion, individual Mrp protein levels, or Mrp complex formation have been identified (Morino et al., 2010).

Accession Number:O05259
Protein Name:MrpB
Length:143
Molecular Weight:15294.00
Species:Bacillus subtilis [1423]
Number of TMSs:4
Location1 / Topology2 / Orientation3: Cell membrane1 / Multi-pass membrane protein2
Substrate sodium(1+), hydron

Cross database links:

RefSeq: NP_391039.1   
Entrez Gene ID: 937177   
Pfam: PF04039   
BioCyc: SUBTI:BSU31610-MONOMER   
KEGG: bsu:BSU31610   

Gene Ontology

GO:0016021 C:integral to membrane
GO:0005886 C:plasma membrane
GO:0015297 F:antiporter activity
GO:0015992 P:proton transport
GO:0006814 P:sodium ion transport

References (5)

[1] “Analysis of the Bacillus subtilis genome: cloning and nucleotide sequence of a 62 kb region between 275 degrees (rrnB) and 284 degrees (pai).”  Oudega B.et.al.   9274030
[2] “The complete genome sequence of the Gram-positive bacterium Bacillus subtilis.”  Kunst F.et.al.   9384377
[3] “mrp, a multigene, multifunctional locus in Bacillus subtilis with roles in resistance to cholate and to Na+ and in pH homeostasis.”  Ito M.et.al.   10198001
[4] “Mrp-dependent Na(+)/H(+) antiporters of Bacillus exhibit characteristics that are unanticipated for completely secondary active transporters.”  Ito M.et.al.   11356194
[5] “Catalytic properties of Staphylococcus aureus and Bacillus members of the secondary cation/proton antiporter-3 (Mrp) family are revealed by an optimized assay in an Escherichia coli host.”  Swartz T.H.et.al.   17293423

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Predict TMSs (Predict number of transmembrane segments)
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FASTA formatted sequence 
1:	MNEQKTNDLI LQTATKLVSF IILLFSFYLF LSGHNAPGGG FVGGLITSSS IVLLLLAYDL 
61:	KTVRSLLPVN FIYVAGAGLL LAVLTGVGSF VFGAPFLTHT FGYFQLPILG KTELATATIF 
121:	DLGVYLVVVG ITMTIIQTIG EEE