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3.A.2.2.5
H -translocating V-type ATPase (Dettmer et al., 2006). The mung bean (Phaseolus aureus) subunits a and c (c' and c") alone catalyzes passive channel-mediated proton flux, but the a,c,d complex does not (Ouyang et al., 2008).  A 4 TMS c-subunit of Tamarix hispida (onion), almost identical to the c-subunit of the A. thaliana homologue, plays a stress tolerance role in response to salt, drought, UV, oxidation, heat, cold, and heavy metals (Gao et al. 2011). The VHA-H subunit is up-regluated upon high salt stress conditions (Yang et al. 2018). The VHAc`1 protein seems to play an important role in plant stress tolerance (Wang et al. 2020).

Accession Number:O23654
Protein Name:V-type proton ATPase catalytic subunit A
Length:623
Molecular Weight:68812.00
Species:Arabidopsis thaliana (Mouse-ear cress) [3702]
Location1 / Topology2 / Orientation3: Vacuole membrane1 / Peripheral membrane protein2
Substrate hydron

Cross database links:

Entrez Gene ID: 844228   
Pfam: PF00006    PF00306    PF02874   
KEGG: ath:AT1G78900   

Gene Ontology

GO:0005618 C:cell wall
GO:0009941 C:chloroplast envelope
GO:0000325 C:plant-type vacuole
GO:0005886 C:plasma membrane
GO:0033180 C:proton-transporting V-type ATPase, V1 domain
GO:0005774 C:vacuolar membrane
GO:0005524 F:ATP binding
GO:0046933 F:hydrogen ion transporting ATP synthase activity, rotational mechanism
GO:0002020 F:protease binding
GO:0046961 F:proton-transporting ATPase activity, rotational mechanism
GO:0015986 P:ATP synthesis coupled proton transport
GO:0007030 P:Golgi organization
GO:0009555 P:pollen development
GO:0009651 P:response to salt stress

References (4)

[1] “Sequence and analysis of chromosome 1 of the plant Arabidopsis thaliana.”  Theologis A.et.al.   11130712
[2] “Empirical analysis of transcriptional activity in the Arabidopsis genome.”  Yamada K.et.al.   14593172
[3] “A simple nomenclature for a complex proton pump: VHA genes encode the vacuolar H(+)-ATPase.”  Sze H.et.al.   11950611
[4] “The deubiquitinating enzyme AMSH3 is required for intracellular trafficking and vacuole biogenesis in Arabidopsis thaliana.”  Isono E.et.al.   20543027

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Predict TMSs (Predict number of transmembrane segments)
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FASTA formatted sequence 
1:	MPAFYGGKLT TFEDDEKESE YGYVRKVSGP VVVADGMAGA AMYELVRVGH DNLIGEIIRL 
61:	EGDSATIQVY EETAGLTVND PVLRTHKPLS VELGPGILGN IFDGIQRPLK TIARISGDVY 
121:	IPRGVSVPAL DKDCLWEFQP NKFVEGDTIT GGDLYATVFE NTLMNHLVAL PPDAMGKITY 
181:	IAPAGQYSLK DTVIELEFQG IKKSYTMLQS WPVRTPRPVA SKLAADTPLL TGQRVLDALF 
241:	PSVLGGTCAI PGAFGCGKTV ISQALSKYSN SDAVVYVGCG ERGNEMAEVL MDFPQLTMTL 
301:	PDGREESVMK RTTLVANTSN MPVAAREASI YTGITIAEYF RDMGYNVSMM ADSTSRWAEA 
361:	LREISGRLAE MPADSGYPAY LAARLASFYE RAGKVKCLGG PERNGSVTIV GAVSPPGGDF 
421:	SDPVTSATLS IVQVFWGLDK KLAQRKHFPS VNWLISYSKY STALESFYEK FDPDFINIRT 
481:	KAREVLQRED DLNEIVQLVG KDALAEGDKI TLETAKLLRE DYLAQNAFTP YDKFCPFYKS 
541:	VWMMRNIIHF YNLANQAVER AAGMDGQKIT YTLIKHRLGD LFYRLVSQKF EDPAEGEDTL 
601:	VEKFKKLYDD LNAGFRALED ETR