3.A.7.12.1
The Cag pathogenicity island (PAI) proteins (Kutter et al., 2008). CagD (Cag24) is essential for CagA translocation and maximal induction of interleukin-8 secretion (Cendron et al., 2009). It is required for a pro-inflammatory response and multiple cytoskeletal and gene regulatory effects in gastric epithelial cells. Its molecular properties are described in a review by Fischer (2011). Cag16 (CagM) (of unknown function and not dermonstrably homologous to proteins of type IV secretion systems in other bacteria) has 3-4 TMSs and is essential for CagA export. It may therefore be a core protein of the Cag complex (Ling et al. 2013).
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| Accession Number: | O25260 |
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| Protein Name: | Cag5 |
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| Length: | 748 |
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| Molecular Weight: | 85778.00 |
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| Species: | Helicobacter pylori (Campylobacter pylori) [210] |
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| Number of TMSs: | 4 |
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| Location1 / Topology2 / Orientation3: |
Membrane1 / Multi-pass membrane protein2 |
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| Substrate |
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1: MEDFLYNTLY FIEDYKLVVI FSFIGLIALF FLYKFIKAQK KAFKDKANQP QKKKSFKEII
61: IDGLKERVKT FGFWLQAILL LSYSFITSGL FFLILLGNFY DDNRSPESDD DLFDIWIYAI
121: QDFPNYYFKA LGFSSLKIYG FNISLVVYGS ILCSYIFITF FVWFLKYLTR TRDIGANKKV
181: DDLFGSASWE TEEKMIKAKL ITPNNKKRAF DKREVIVGRR GLGDFIAYAG QAFIGLIAPT
241: RSGKGVGFIM PNMINYPQNI VVFDPKADTM ETCGKIREKR FNQKVFIYEP FSLKTHRFNP
301: FAYVDFGNDV VLTEDILSQI DTRLKGHGMV ASGGDFSTQI FGLAKLVFPE RPNEKDPFFS
361: NQARNLFVIN CNIYRDLMWT KKGLEFVKRK KIIMPETPTM FFIGSMASGI NLIDEDTNME
421: KVVSLMEFFG GEEDKSGDNL RVLSPATRNM WNSFKTMGGA RETYSSVQGV YTSAFAPYNN
481: AMIRNFTSAN DFDFRRLRID EVSIGVIANP KESTIVGPIL ELFFNVMIYS NLILPIHDPQ
541: CKRSCLMLMD EFTLCGYLET FVKAVGIMAE YNMRPAFVFQ SKAQLENDPP LGYGRNGAKT
601: ILDNLSLNMY YGINNDNYYE HFEKLSKVLG KYTRQDVSRS IDDNTGKTNT SISNKERFLM
661: TPDELMTMGD ELIILENTLK PIKCHKALYY DDPFFTDELI KVSPSLSKKY KLGKVPNQAT
721: FYDDLQAAKT RGELSYDKSL VPVGSSEL