3.A.7.12.1
The Cag pathogenicity island (PAI) proteins (Kutter et al., 2008). CagD (Cag24) is essential for CagA translocation and maximal induction of interleukin-8 secretion (Cendron et al., 2009). It is required for a pro-inflammatory response and multiple cytoskeletal and gene regulatory effects in gastric epithelial cells. Its molecular properties are described in a review by Fischer (2011). Cag16 (CagM) (of unknown function and not dermonstrably homologous to proteins of type IV secretion systems in other bacteria) has 3-4 TMSs and is essential for CagA export. It may therefore be a core protein of the Cag complex (Ling et al. 2013).
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| Accession Number: | O25262 |
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| Protein Name: | Cag7 |
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| Length: | 1927 |
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| Molecular Weight: | 219401.00 |
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| Species: | Helicobacter pylori (Campylobacter pylori) [210] |
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| Number of TMSs: | 5 |
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| Location1 / Topology2 / Orientation3: |
Membrane1 / Multi-pass membrane protein2 |
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| Substrate |
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1: MNEENDKLET SKKAQQDSPQ DLSNEEATEA NHFENLLKES KESSDHHLDN PTETQTHFDG
61: DKSEETQTQM DSEGNETSES SNGSLADKLF KKARKLVDNK KPFTQQKNLD EETQELNEED
121: DQENNEYQEE TQTDLIDDET SKKTQQHSPQ DLSNEEATEA NHFENLLKES KESSDHHLDN
181: PTETQTNFDG DKSEETQTQM DSEGNETSES SNGSLADKLF KKARKLVDNK KPFTQQKNLD
241: EETQELNEED DQENNEYQEE TQTDLIDDET SKKTQQHSPQ DLSNEEATEA NHFENLLKES
301: KESSDHHLDN PTETQTNFDG DKSEEITDDS NDQEIIKGSK KKYIIGGIVV AVLIVIILFS
361: RSIFHYFMPL EDKSSRFSKD RNLYVNDEIQ IRQEYNRLLK ERNEKGNMID KNLFFNDDPN
421: RTLYNYLNIA EIEDKNPLRA FYECISNGGN YEECLKLIKD KKLQDQMKKT LEAYNDCIKN
481: AKTEEERIKC LDLIKDENLK KSLLNQQKVQ VALDCLKNAK TDEERNECLK LINDPEIREK
541: FRKELELQKE LQEYKDCIKN AKTEAEKNKC LKGLSKEAIE RLKQQALDCL KNAKTDEERN
601: ECLKNIPQDL QKELLADMSV KAYKDCVSKA RNEKEKQECE KLLTPEARKK LEQQVLDCLK
661: NAKTDEERKK CLKDLPKDLQ SDILAKESLK AYKDCVSQAK TEAEKKECEK LLTPEAKKLL
721: EEEAKESVKA YLDCVSQAKT EAEKKECEKL LTPEAKKKLE EAKKSVKAYL DCVSRARNEK
781: EKKECEKLLT PEAKKLLEQQ ALDCLKNAKT DKERKKCLKD LPKDLQKKVL AKESVKAYLD
841: CVSQAKTEAE KKECEKLLTP EARKLLEEAK KSVKAYLDCV SQAKTEAEKK ECEKLLTPEA
901: RKLLEEXAKE SVKAYLDCVS QAKNEAEKKE CEKLLTLESK KKLEEAKKSV KAYLDCVSQA
961: KTEAEKKECE KLLTPEAKKL LEQQALDCLK NAKTEADKKR CVKDLPKDLQ KKVLAKESLK
1021: AYKDCVSKAR NEKEKKECEK LLTPEAKKLL EEAKKSVKAY LDCVSQAKTE AEKKECEKLL
1081: TPEARKLLEE AKESVKAYKD CVSKARNEKE KKECEKLLTP EAKKLLEQQV LDCLKNAKTE
1141: ADKKRCVKDL PKDLQKKVLA KESVKAYLDC VSRARNEKEK KECEKLLTPE AKKLLEEAKE
1201: SLKAYKDCLS QARNEEERRA CEKLLTPEAR KLLEQEVKKS IKAYLDCVSR ARNEKEKKEC
1261: EKLLTPEARK FLAKQVLNCL EKAGNEEERK ACLKNLPKDL QENILAKESL KAYKDCLSQA
1321: RNEEERRACE KLLTPEARKL LEQEVKKSVK AYLDCVSRAR NEKEKKECEK LLTPEARKFL
1381: AKELQQKDKA IKDCLKNADP NDRAAIMKCL DGLSDEEKLK YLQEAREKAV ADCLAMAKTD
1441: EEKRKCQNLY SDLIQEIQNK RTQNKQNQLS KTERLHQASE CLDNLDDPTD QEAIEQCLEG
1501: LSDSERALIL GIKRQADEVD LIYSDLRNRK TFDNMAAKGY PLLPMDFKNG GDIATINATN
1561: VDADKIASDN PIYASIEPDI AKQYETEKTI KDKNLEAKLA KALGGNKKDD DKEKSKKSTA
1621: EAKAENNKID KDVAETAKNI SEIALKNKKE KSGEFVDENG NPIDDKKKAE KQDETSPVKQ
1681: AFIGKSDPTF VLAQYTPIEI TLTSKVDATL TGIVSGVVAK DVWNMNGTMI LLDKGTKVYG
1741: NYQSVKGGTP IMTRLMIVFT KAITPDGVII PLANAQAAGM LGEAGVDGYV NNHFMKRIGF
1801: AVIASVVNSF LQTAPIIALD KLIGLGKGRS ERTPEFNYAL GQAINGSMQS SAQMSNQILG
1861: QLMNIPPSFY KNEGDSIKIL TMDDIDFSGV YDVKITNKSV VDEIIKQSTK TLSREHEEIT
1921: TSPKGGN