3.A.7.12.1
The Cag pathogenicity island (PAI) proteins (Kutter et al., 2008). CagD (Cag24) is essential for CagA translocation and maximal induction of interleukin-8 secretion (Cendron et al., 2009). It is required for a pro-inflammatory response and multiple cytoskeletal and gene regulatory effects in gastric epithelial cells. Its molecular properties are described in a review by Fischer (2011). Cag16 (CagM) (of unknown function and not dermonstrably homologous to proteins of type IV secretion systems in other bacteria) has 3-4 TMSs and is essential for CagA export. It may therefore be a core protein of the Cag complex (Ling et al. 2013).
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| Accession Number: | O25263 |
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| Protein Name: | Cag8 |
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| Length: | 522 |
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| Molecular Weight: | 60625.00 |
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| Species: | Helicobacter pylori (Campylobacter pylori) [210] |
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| Number of TMSs: | 1 |
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| Location1 / Topology2 / Orientation3: |
Membrane1 / Multi-pass membrane protein2 |
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| Substrate |
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1: MGQAFFKKIV GCFCLGYLFL SSAIEAAALD IKNFNRGRVK VVNKKIAYLG DEKPITIWTS
61: LDNVTVIQLE KDETISYITT GFNKGWSIVP NSNHIFIQPK SVKSNLMFEK EAVNFALMTR
121: DYQEFLKTKK LIVDAPDPKE LEEQKKALEK EKEAKEQAQK AQKDKREKRK EERAKNRANL
181: ENLTNAMSNP QNLSNNKNLS EFIKQQRENE LDQMERLEDM QEQAQANALK QIEELNKKQA
241: EETIKQRAKD KINIKTDKPQ KSPEDNSIEL SPSDSAWRTN LVVRTNKALY QFILRIAQKD
301: NFASAYLTVK LEYPQRHEVS SVIEEELKKR EEAKRQKELI KQENLNTTAY INRVMMASNE
361: QIINKEKIRE EKQKIILDQA KALETQYVHN ALKRNPVPRN YNYYQAPEKR SKHIMPSEIF
421: DDGTFTYFGF KNITLQPAIF VVQPDGKLSM TDAAIDPNMT NSGLRWYRVN EIAEKFKLIK
481: DKALVTVINK GYGKNPLTKN YNIKNYGELE RVIKKLPLVR DK