3.A.7.12.1
The Cag pathogenicity island (PAI) proteins (Kutter et al., 2008). CagD (Cag24) is essential for CagA translocation and maximal induction of interleukin-8 secretion (Cendron et al., 2009). It is required for a pro-inflammatory response and multiple cytoskeletal and gene regulatory effects in gastric epithelial cells. Its molecular properties are described in a review by Fischer (2011). Cag16 (CagM) (of unknown function and not dermonstrably homologous to proteins of type IV secretion systems in other bacteria) has 3-4 TMSs and is essential for CagA export. It may therefore be a core protein of the Cag complex (Ling et al. 2013).
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| Accession Number: | O25264 |
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| Protein Name: | Cag9 |
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| Length: | 535 |
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| Molecular Weight: | 57737.00 |
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| Species: | Helicobacter pylori (Campylobacter pylori) [210] |
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| Number of TMSs: | 12 |
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| Location1 / Topology2 / Orientation3: |
Membrane1 / Multi-pass membrane protein2 |
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| Substrate |
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1: MFNIKRNFLI TIISFFLIVP NWLKAIDLPI VSNLKIYQTV YCMLIPSYVL TNKSFADILT
61: GYTSIGASGS GKSSGQGVIE ALSTPLATSL AASNLVKYLN TLGPLWGSAW ASVATAIQGF
121: ALTPSSGCNF GWNALINKNI DVSMDSVLDN LSNKIQNFTK GGVEDNVKGN ILLQIIGSIT
181: AQASTNITAD GLIWLIGKEF TANKLQNNTT AMLAFAALES VVKGADAAVL PAYGVVNLPD
241: IIIGQGSYLD FVSYLIYIVF GIFVFISFMK LRDISSNIQI NIGFEYMRFV GGTLFKMAMV
301: SFIAYAGFGY LYKISYSIYF GLAGAFGLNQ VLFWALDLVL NYTVNSILPA VRAVFSNVGN
361: NAPSLLQGLQ VAGISLFAIF MQVTIIMRIS TVVVKPLIAG AFSGIVFPIA VSLIVLDWFK
421: DSMKNILIWF INNLFILVLA IPILLFGVLA LLAFNLTITP SVAIQNINQG GLGIDSTIAS
481: LITLFILKGF IETIIESVNA IVNTIFSSVS MDGSRMDRER DALMVGRVGG SMFKG