3.A.7.12.1
The Cag pathogenicity island (PAI) proteins (Kutter et al., 2008). CagD (Cag24) is essential for CagA translocation and maximal induction of interleukin-8 secretion (Cendron et al., 2009). It is required for a pro-inflammatory response and multiple cytoskeletal and gene regulatory effects in gastric epithelial cells. Its molecular properties are described in a review by Fischer (2011). Cag16 (CagM) (of unknown function and not dermonstrably homologous to proteins of type IV secretion systems in other bacteria) has 3-4 TMSs and is essential for CagA export. It may therefore be a core protein of the Cag complex (Ling et al. 2013).
|
| Accession Number: | O25274 |
|---|
| Protein Name: | Cag20 |
|---|
| Length: | 370 |
|---|
| Molecular Weight: | 39437.00 |
|---|
| Species: | Helicobacter pylori (Campylobacter pylori) [210] |
|---|
| Number of TMSs: | 1 |
|---|
| Location1 / Topology2 / Orientation3: |
Membrane1 / Multi-pass membrane protein2 |
|---|
| Substrate |
|
|---|
1: MAGTQAIYES SSAGFLSEIS SIISSTSGVA GPFAGIVAGA MSAAIIPIVV GFTNPQMTAI
61: MTQYNQSIAE AVSMPMKAAN QQYNQLYQGF NDQSMAVGNN ILNISKLTGE FNVQGNTQGA
121: QISAVNSQIA SILASNTTPK NPSAIEAYAT NQIAVPSVPT TVEMMSGILG NITSAAPKYA
181: LALQEQLRSQ ASNSSMNDTA DSLDSCTALG ALVGSSKVFF SCMQISMTPM SVSMPTVYAK
241: YQALXTNALT SGTNPMTTPA CPIGDKVLAV YCYAEKVAEI LREYYIEFVK NNTNLLQNAS
301: QMILNQSGLA TSTYDTQAIS NISSLYNYNI VANKSFLKSH LTYLDYIKNK LKGQKDSYLT
361: ERVQTKIIVK