3.A.1.122.2
The SpdC antimicrobial peptide resistance efflux pump, YknXYZ (Butcher and Helmann, 2006). YknW (TC# 9.B.29.2.17), a 5 TMS protein, interacts directly with YknXYZ and is essential for facilitation of its assembly, thus serving as an integral membrane chaparone (Yamada et al., 2012). The MFP YknX requires the ATP-binding cassette (ABC) transporter YknYZ
and the Yip1 family protein YknW to form a functional complex. YknX (MFP) is hexameric (Xu et al. 2017).
|
| Accession Number: | O31712 |
|---|
| Protein Name: | Uncharacterized ABC transporter permease yknZ |
|---|
| Length: | 397 |
|---|
| Molecular Weight: | 42125.00 |
|---|
| Species: | Bacillus subtilis (strain 168) [224308] |
|---|
| Number of TMSs: | 4 |
|---|
| Location1 / Topology2 / Orientation3: |
Cell membrane1 / Multi-pass membrane protein2 |
|---|
| Substrate |
|
|---|
1: MSLLENIRMA LSSVLAHKMR SILTMLGIII GVGSVIVVVA VGQGGEQMLK QSISGPGNTV
61: ELYYMPSDEE LASNPNAAAE STFTENDIKG LKGIEGIKQV VASTSESMKA RYHEEETDAT
121: VNGINDGYMN VNSLKIESGR TFTDNDFLAG NRVGIISQKM AKELFDKTSP LGEVVWINGQ
181: PVEIIGVLKK VTGLLSFDLS EMYVPFNMMK SSFGTSDFSN VSLQVESADD IKSAGKEAAQ
241: LVNDNHGTED SYQVMNMEEI AAGIGKVTAI MTTIIGSIAG ISLLVGGIGV MNIMLVSVTE
301: RTREIGIRKS LGATRGQILT QFLIESVVLT LIGGLVGIGI GYGGAALVSA IAGWPSLISW
361: QVVCGGVLFS MLIGVIFGML PANKAAKLDP IEALRYE