8.A.217.1.1
The massive protein machine that regulates cell death/apoptosis, BIRC6 is a subunit of 4857 aas with one BIR domain. The complex regulates several caspases (caspase3, caspase7 and caspase9 as well as Omi; see below), BIRC6, SMAC, several IAPs (inhibitors of apoptosis), and ACDR (Apoptosis Cell Death Regulator).
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| Accession Number: | O43464 |
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| Protein Name: | Serine protease HTRA2, mitochondrial |
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| Length: | 458 |
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| Molecular Weight: | 48841.00 |
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| Species: | Homo sapiens (Human) [9606] |
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| Number of TMSs: | 2 |
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| Location1 / Topology2 / Orientation3: |
Endoplasmic reticulum1 |
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| Substrate |
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1: MAAPRAGRGA GWSLRAWRAL GGIRWGRRPR LTPDLRALLT SGTSDPRARV TYGTPSLWAR
61: LSVGVTEPRA CLTSGTPGPR AQLTAVTPDT RTREASENSG TRSRAWLAVA LGAGGAVLLL
121: LWGGGRGPPA VLAAVPSPPP ASPRSQYNFI ADVVEKTAPA VVYIEILDRH PFLGREVPIS
181: NGSGFVVAAD GLIVTNAHVV ADRRRVRVRL LSGDTYEAVV TAVDPVADIA TLRIQTKEPL
241: PTLPLGRSAD VRQGEFVVAM GSPFALQNTI TSGIVSSAQR PARDLGLPQT NVEYIQTDAA
301: IDFGNSGGPL VNLDGEVIGV NTMKVTAGIS FAIPSDRLRE FLHRGEKKNS SSGISGSQRR
361: YIGVMMLTLS PSILAELQLR EPSFPDVQHG VLIHKVILGS PAHRAGLRPG DVILAIGEQM
421: VQNAEDVYEA VRTQSQLAVQ IRRGRETLTL YVTPEVTE