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3.A.7.2.1 Trw conjugation system of E. coli plasmid IncP. The hexameric form of TrwK is a catalytically active ATPase, much like the structurally related protein TrwB, the conjugative coupling protein (Arechaga et al, 2008), which is a structure-specific DNA-binding protein (Matilla et al., 2010)
Accession Number:	O50333
Protein Name:	TrwI
Length:	342
Molecular Weight:	35221.00
Species:	Escherichia coli [562]
Number of TMSs:	7
Location¹ / Topology² / Orientation³:	Host membrane¹ / Multi-pass membrane protein²
Substrate	protein polypeptide chain

Pfam:	PF04610
Gene Ontology GO:0000747 P:conjugation with cellular fusion
References (9) [1] “Genetic organization of the region involved in conjugative pilus synthesis, export and assembly of the incW plasmid R388.” Bolland S.et.al. 9325277 [2] “Functional analysis of unique class II insertion sequence IS1071.” Sota M.et.al. 16391056 [3] “DNA sequence of a plasmid-encoded dihydrofolate reductase.” Swift G.et.al. 7022127 [4] “Site-specific recombination promotes linkage between trimethoprim-and sulfonamide resistance genes. Sequence characterization of dhfrV and sulI and a recombination active locus of Tn21.” Sundstroem L.et.al. 3054482 [5] “Structural and functional analysis of the origin of conjugal transfer of the broad-host-range IncW plasmid R388 and comparison with the related IncN plasmid R46.” Llosa M.et.al. 2038309 [6] “Genetic organization of the conjugal DNA processing region of the IncW plasmid R388.” Llosa M.et.al. 8289274 [7] “Integrons found in different locations have identical 5' ends but variable 3' ends.” Hall R.M.et.al. 7929000 [8] “Characterization and movement of the class 1 integron known as Tn2521 and Tn1405.” Partridge S.R.et.al. 11959558 [9] “The VirB4 family of proposed traffic nucleoside triphosphatases: common motifs in plasmid RP4 TrbE are essential for conjugation and phage adsorption.” Rabel C.et.al. 12533481

UniProt (Universal Protein Resource)
CDD Search (Conserved Domain Database)

Predict TMSs (Predict number of transmembrane segments)

FASTA formatted sequence

1:	MAFELFTPLF NKIDQTTATY VTDISSRAIA AITPVVSVGL TLGFITYGWL IIRGAVEMPV 
61:	AEFLNRCLRI GIIVSIALAG GLYQGEIANA ITTVPDELAS ALLGNPTEGA SAAALVDQSA 
121:	QQGFDRASEA FEEAGFFSSD GLLYGLFGII IPAGYGPAGA IGGAFLLLAK IALALLAGLG 
181:	PLFILALIWQ PTHRFFDQWA QQVLNYGLLI VLFAAVFGLL MQIFGSYMAD LRFDGAQNVA 
241:	YAIGGSVILS IVSIVLLMQL PSIASGLAGG IGLGYMWELR SMRSGAGAAM RGGRAMARGA 
301:	RAAPGAARGA AVGAANMAKT VATGGAGVAR AAAGYFRGRK AG

3.A.7.2.1
Trw conjugation system of E. coli plasmid IncP. The hexameric form of TrwK is a catalytically active ATPase, much like the structurally related protein TrwB, the conjugative coupling protein (Arechaga et al, 2008), which is a structure-specific DNA-binding protein (Matilla et al., 2010)

Cross database links:

Gene Ontology

References (9)

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3.A.7.2.1Trw conjugation system of E. coli plasmid IncP. The hexameric form of TrwK is a catalytically active ATPase, much like the structurally related protein TrwB, the conjugative coupling protein (Arechaga et al, 2008), which is a structure-specific DNA-binding protein (Matilla et al., 2010)

Cross database links:

Gene Ontology

References (9)

External Searches:

Analyze:

3.A.7.2.1
Trw conjugation system of E. coli plasmid IncP. The hexameric form of TrwK is a catalytically active ATPase, much like the structurally related protein TrwB, the conjugative coupling protein (Arechaga et al, 2008), which is a structure-specific DNA-binding protein (Matilla et al., 2010)