1.P.1.1.1
The SV40 ER membrane penitration complex involving the DnaJ-B12 protein of 375 aas and 1 TMS or the transmembrane J-protein B14 as well as Erlin1 (SPFH1; 346 aas and 1 TMS) and Erlin2 (SPFH2; 339 aas and 1 TMS) (Inoue and Tsai 2017). Kinesin-1 (KIF5B or KNS1) may serve as the motor (Ravindran et al. 2017). See family description for details.
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| Accession Number: | O75477 |
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| Protein Name: | Erlin-1 |
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| Length: | 346 |
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| Molecular Weight: | 38926.00 |
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| Species: | Homo sapiens (Human) [9606] |
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| Number of TMSs: | 1 |
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| Location1 / Topology2 / Orientation3: |
Endoplasmic reticulum membrane1 / Single-pass type II membrane protein2 |
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| Substrate |
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1: MTQARVLVAA VVGLVAVLLY ASIHKIEEGH LAVYYRGGAL LTSPSGPGYH IMLPFITTFR
61: SVQTTLQTDE VKNVPCGTSG GVMIYIDRIE VVNMLAPYAV FDIVRNYTAD YDKTLIFNKI
121: HHELNQFCSA HTLQEVYIEL FDQIDENLKQ ALQKDLNLMA PGLTIQAVRV TKPKIPEAIR
181: RNFELMEAEK TKLLIAAQKQ KVVEKEAETE RKKAVIEAEK IAQVAKIRFQ QKVMEKETEK
241: RISEIEDAAF LAREKAKADA EYYAAHKYAT SNKHKLTPEY LELKKYQAIA SNSKIYFGSN
301: IPNMFVDSSC ALKYSDIRTG RESSLPSKEA LEPSGENVIQ NKESTG