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2.A.6.2.24 The multidrug (aminoglycosides (e.g., streptomycin, gentamycin, neomycin, tobramycin, kanamycin and spectinomycin) and macrolides (e.g., erythromycin and clarithromycin, but not lincosamide and clindamycin)) efflux pump, AmrAB-OprA (Moore et al., 1999)
Accession Number:	O87935
Protein Name:	AmrA
Length:	399
Molecular Weight:	42479.00
Species:	Burkholderia pseudomallei (Pseudomonas pseudomallei) [28450]
Location¹ / Topology² / Orientation³:	Cell membrane¹ / Multi-pass membrane protein²
Substrate	streptomycin, gentamycin, tobramycin, erythromycin A, kanamycin, neomycin, clindamycin, spectinomycin, clarithromycin

Pfam:	PF00529
Gene Ontology GO:0016020 C:membrane GO:0008565 F:protein transporter activity GO:0009306 P:protein secretion
References (1) [1] “Efflux-mediated aminoglycoside and macrolide resistance in Burkholderia pseudomallei.” Moore R.A.et.al. 10049252

UniProt (Universal Protein Resource)
CDD Search (Conserved Domain Database)

Predict TMSs (Predict number of transmembrane segments)

FASTA formatted sequence

1:	MKYEWARTRR LSAALAVAAF VAAGCGKHES EHDAAAPREA SVVTVKKTSV PLSVELPGRL 
61:	DAYRQAEVRA RVAGIVTART YEEGQEVKRG AVLFRIDPAP FKAARDAAAG ALEKAQAAHL 
121:	AALDKRRRYD ELVRDRAVSE RDHTEALADE RQAKAAVASA RAELARAQLQ LDYATVTAPI 
181:	DGRARRALVT EGALVGQDQA TPLTTVEQLD PIYVNFSQPA ADVESLRRAV KSGRAAGIAQ 
241:	QDVEVTLVRP DGSTYARKGK LLFADLAVDP STDTVAMRAL FPNPERELLP GAYVRIALDR 
301:	AVARDAILVP RDALLRTADS ATVKVVGQNG KIRDVTVEAA QMKGRDWIVT RGLAGGERVV 
361:	VVDAAQFEAG TTVKALERGA AAQPASGAAA ASAPGRRST

2.A.6.2.24
The multidrug (aminoglycosides (e.g., streptomycin, gentamycin, neomycin, tobramycin, kanamycin and spectinomycin) and macrolides (e.g., erythromycin and clarithromycin, but not lincosamide and clindamycin)) efflux pump, AmrAB-OprA (Moore et al., 1999)

Cross database links:

Gene Ontology

References (1)

External Searches:

Analyze:

2.A.6.2.24The multidrug (aminoglycosides (e.g., streptomycin, gentamycin, neomycin, tobramycin, kanamycin and spectinomycin) and macrolides (e.g., erythromycin and clarithromycin, but not lincosamide and clindamycin)) efflux pump, AmrAB-OprA (Moore et al., 1999)

Cross database links:

Gene Ontology

References (1)

External Searches:

Analyze:

2.A.6.2.24
The multidrug (aminoglycosides (e.g., streptomycin, gentamycin, neomycin, tobramycin, kanamycin and spectinomycin) and macrolides (e.g., erythromycin and clarithromycin, but not lincosamide and clindamycin)) efflux pump, AmrAB-OprA (Moore et al., 1999)