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2.A.6.2.24 The multidrug (aminoglycosides (e.g., streptomycin, gentamycin, neomycin, tobramycin, kanamycin and spectinomycin) and macrolides (e.g., erythromycin and clarithromycin, but not lincosamide and clindamycin)) efflux pump, AmrAB-OprA (Moore et al., 1999)
Accession Number:	O87936
Protein Name:	AmrB
Length:	1043
Molecular Weight:	111217.00
Species:	Burkholderia pseudomallei (Pseudomonas pseudomallei) [28450]
Number of TMSs:	12
Location¹ / Topology² / Orientation³:	Cell membrane¹ / Multi-pass membrane protein²
Substrate	streptomycin, gentamycin, tobramycin, erythromycin A, kanamycin, neomycin, clindamycin, spectinomycin, clarithromycin

Pfam:	PF00873
Gene Ontology GO:0016021 C:integral to membrane GO:0005215 F:transporter activity GO:0006810 P:transport
References (1) [1] “Efflux-mediated aminoglycoside and macrolide resistance in Burkholderia pseudomallei.” Moore R.A.et.al. 10049252

UniProt (Universal Protein Resource)
CDD Search (Conserved Domain Database)

Predict TMSs (Predict number of transmembrane segments)

FASTA formatted sequence

1:	MARFFIDRPV FAWVISLFIM LGGIFAIRAL PVAQYPDIAP PVVSLYATYP GASAQVVEES 
61:	VTAVIEREMN GVPGLLYTSA TSSAGQASLS LTFKQGVSAD LAAVDVQNRL KIVEARLPEP 
121:	VRRDGISIEK AADNAQIIVS LTSEDGRISG VELGEYASAN VLQALRRVEG VGKVQFWGAE 
181:	YAMRIWPDPV KMAALGLTAS DIASAVRAHN ARVTIGDVGR SAVPDSAPIA ATVLADAPLT 
241:	TPDAFGAIAL RARADGSTLY LRDVARIEFG GNDYNYPSFV NGKTATGMGI KLAPGSNAVA 
301:	TEKRVRATME ELAKFFPPGV KYQIPYETAS FVRVSMSKVV TTLVEAGVLV FAVMFLFMQN 
361:	FRATLIPTLV VPVALLGTFG AMLAAGFSIN VLTMFGMVLA IGILVDDAIV VVENVERLMV 
421:	EEKLPPYEAT VKAMKQISGA IVGITVVLTS VFVPMAFFGG AVGNIYRQFA FALAVSIGFS 
481:	AFLALSLTPA LCATLLKPVA DDHHEKDGFF GWFNRFVARS THRYTRRVGR VLERPLRWLV 
541:	VYGALTAAAA LLITKLPAAF LPDEDQGNFM VMVIRPQGTP LAETMQSVRR VEEYVRTHSP 
601:	SAYTFALGGY NLYGEGPNGG MIFVTMKDWK ERKRARDQVQ AIIAEINAHF AGTPNTMVFA 
661:	INMPALPDLG LTGGFDFRLQ DRGGLGYGAF VAAREKLLAE GRKDPVLTDL MFAGTQDAPQ 
721:	LKLDIDRAKA SALGVSMEEI NATLAVMFGS DYIGDFMHGS QVRRVIVQAD GRHRLDAADV 
781:	TKLRVRNAKG EMVPLAAFAT LHWTMGPPQL TRYNGFPSFT INGAASAGHS SGEAMAAIER 
841:	IASTLPAGTG YAWSGQSYEE RLSGAQAPML FALSVLVVFL ALAALYESWS IPFAVMLVVP 
901:	LGVIGAVAGV TLRGMPNDIY FKVGLIATIG LSAKNAILIV EVAKDLVAQR MSLADAALEA 
961:	ARLRLRPIVM TSLAFGVGVL PLAFATGAAS GAQIAIGTGV LGGVISATLF AIFLVPLFFV 
1021:	CVGRVFDVVP RRPGGAQAAL EAK

2.A.6.2.24
The multidrug (aminoglycosides (e.g., streptomycin, gentamycin, neomycin, tobramycin, kanamycin and spectinomycin) and macrolides (e.g., erythromycin and clarithromycin, but not lincosamide and clindamycin)) efflux pump, AmrAB-OprA (Moore et al., 1999)

Cross database links:

Gene Ontology

References (1)

External Searches:

Analyze:

2.A.6.2.24The multidrug (aminoglycosides (e.g., streptomycin, gentamycin, neomycin, tobramycin, kanamycin and spectinomycin) and macrolides (e.g., erythromycin and clarithromycin, but not lincosamide and clindamycin)) efflux pump, AmrAB-OprA (Moore et al., 1999)

Cross database links:

Gene Ontology

References (1)

External Searches:

Analyze:

2.A.6.2.24
The multidrug (aminoglycosides (e.g., streptomycin, gentamycin, neomycin, tobramycin, kanamycin and spectinomycin) and macrolides (e.g., erythromycin and clarithromycin, but not lincosamide and clindamycin)) efflux pump, AmrAB-OprA (Moore et al., 1999)