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1.A.56.1.5
The heterodimeric high affinity copper uptake transporter, Ctr4/Ctr5. The Ctr4 central domain may mediate Cu2+ transport in this hetero-complex, whereas the Ctr5 carboxyl-terminal domain functions in the regulation of trafficking of the Cu2+ transport complex to the cell surface (Beaudoin et al., 2011).

Accession Number:O94722
Protein Name:Ctr4 aka SPCC1393.10
Length:289
Molecular Weight:32020.00
Species:Schizosaccharomyces pombe (Fission yeast) [4896]
Number of TMSs:3
Location1 / Topology2 / Orientation3: Membrane1 / Multi-pass membrane protein2
Substrate copper(2+)

Cross database links:

RefSeq: NP_587968.1   
Entrez Gene ID: 2538731   
Pfam: PF04145   
KEGG: spo:SPCC1393.10   

Gene Ontology

GO:0005783 C:endoplasmic reticulum
GO:0016021 C:integral to membrane
GO:0005886 C:plasma membrane
GO:0005375 F:copper ion transmembrane transporter activity
GO:0046982 F:protein heterodimerization activity
GO:0006825 P:copper ion transport

References (4)

[1] “A copper-sensing transcription factor regulates iron uptake genes in Schizosaccharomyces pombe.”  Labbe S.et.al.   10593913
[2] “The genome sequence of Schizosaccharomyces pombe.”  Wood V.et.al.   11859360
[3] “Identification of a novel high affinity copper transport complex in the fission yeast Schizosaccharomyces pombe.”  Zhou H.et.al.   11274192
[4] “Phosphoproteome analysis of fission yeast.”  Wilson-Grady J.T.et.al.   18257517

External Searches:

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Predict TMSs (Predict number of transmembrane segments)
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FASTA formatted sequence 
1:	MSFFSAAKQS LGNSLIKLGT SMAQNSQGPV DDSSLSQLEN LLPPLQILTA RAAMAAMNMS 
61:	NDTSMSGMNM TNSTTPMSGM NMTNSTTSMS GMNMSNSTTS MSGMNMTNTT TTAKASSCKL 
121:	SMYWNWYTID ACFITKHWHI TSKHMFVGSI FGIIFMMMAL ELVRRGQREF DRWCVRRFSP 
181:	ASNSCCHSGA PVHSGPSMAL RIFLHFLRSC FYLVQYIVAY IAMLLAMYYN GYVILFLFCG 
241:	TFFGYFLFGA DTISTKASSS VQTKTIVQVA DEKHEHDSSQ YSDTTPTTE