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3.D.3.3.1
Ubiquinol:cytochrome c oxidoreductase.  The cytochrome bc1 complex resides in the inner membrane of mitochondria and transfers electrons from ubiquinol to cytochrome c. This electron transfer is coupled to the translocation of protons across the membrane by the protonmotive Q cycle mechanism. This mechanism topographically separates reduction of quinone and reoxidation of quinol at sites on opposite sites of the membrane, referred to as the center N (Qn site) and the center P (Qp site), respectively. Both are located on cytochrome b, a transmembrane protein of the bc1 complex that is encoded on the mitochondrial genome (Ding et al. 2006).

Accession Number:P00163
Protein Name:CYB aka COB aka CYTB aka Q0105
Length:385
Molecular Weight:43656.00
Species:Saccharomyces cerevisiae (Baker's yeast) [4932]
Number of TMSs:9
Location1 / Topology2 / Orientation3: Mitochondrion inner membrane1 / Multi-pass membrane protein2
Substrate hydron

Cross database links:

RefSeq: NP_009315.1   
Entrez Gene ID: 854583   
Pfam: PF00032    PF00033   
KEGG: sce:Q0105   

Gene Ontology

GO:0016021 C:integral to membrane
GO:0005750 C:mitochondrial respiratory chain complex III
GO:0045153 F:electron transporter, transferring electron...
GO:0046872 F:metal ion binding
GO:0016491 F:oxidoreductase activity
GO:0009060 P:aerobic respiration
GO:0006122 P:mitochondrial electron transport, ubiquinol...
GO:0006810 P:transport

References (9)

[1] “Assembly of the mitochondrial membrane system. DNA sequence and organization of the cytochrome b gene in Saccharomyces cerevisiae D273-10B.”  Nobrega F.G.et.al.   6253454
[2] “Revision of the nucleotide sequence at the last intron of the mitochondrial apocytochrome b gene in Saccharomyces cerevisiae.”  Bonjardim C.A.et.al.   6383504
[3] “Limitations to in vivo import of hydrophobic proteins into yeast mitochondria. The case of a cytoplasmically synthesized apocytochrome b.”  Claros M.G.et.al.   7737175
[4] “The complete sequence of the mitochondrial genome of Saccharomyces cerevisiae.”  Foury F.et.al.   9872396
[5] “Sequence of introns and flanking exons in wild-type and box3 mutants of cytochrome b reveals an interlaced splicing protein coded by an intron.”  Lazowska J.et.al.   7004642
[6] “Splice points of the third intron in the yeast mitochondrial cytochrome b gene.”  Lazowska J.et.al.   7034963
[7] “Electron-transfer restoration by vitamin K3 in a complex III-deficient mutant of S. cerevisiae and sequence of the corresponding cytochrome b mutation.”  Brivet-Chevillotte P.et.al.   2551731
[8] “Structure at 2.3 A resolution of the cytochrome bc1 complex from the yeast Saccharomyces cerevisiae co-crystallized with an antibody Fv fragment.”  Hunte C.et.al.   10873857
[9] “Crystal structure of the yeast cytochrome bc1 complex with its bound substrate cytochrome c.”  Lange C.et.al.   11880631
Structure:
1EZV   1KB9   1KYO   1P84   2IBZ   3CX5   3CXH   4PD4   6GIQ   6HU9   [...more]

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FASTA formatted sequence 
1:	MAFRKSNVYL SLVNSYIIDS PQPSSINYWW NMGSLLGLCL VIQIVTGIFM AMHYSSNIEL 
61:	AFSSVEHIMR DVHNGYILRY LHANGASFFF MVMFMHMAKG LYYGSYRSPR VTLWNVGVII 
121:	FILTIATAFL GYCCVYGQMS HWGATVITNL FSAIPFVGND IVSWLWGGFS VSNPTIQRFF 
181:	ALHYLVPFII AAMVIMHLMA LHIHGSSNPL GITGNLDRIP MHSYFIFKDL VTVFLFMLIL 
241:	ALFVFYSPNT LGHPDNYIPG NPLVTPASIV PEWYLLPFYA ILRSIPDKLL GVITMFAAIL 
301:	VLLVLPFTDR SVVRGNTFKV LSKFFFFIFV FNFVLLGQIG ACHVEVPYVL MGQIATFIYF 
361:	AYFLIIVPVI STIENVLFYI GRVNK