Search TCDB: (?)
TCDB is operated by the Saier Lab Bioinformatics Group
« See all members of the family


3.D.4.8.1
Cytochrome oxidase (Cox).  The factors limiting the allotopic production of the Cox2 subunit of yeast cytochrome c oxidase have been discovered (Nieto-Panqueva et al. 2024). The biogenesis pathway followed by the allotopically produced Cox2 subunit based on the participation of the 2 different structural/functional forms of the TIM23 translocon, TIM23MOTOR and TIM23SORT must follow a concerted and sequential mode of action to insert Cox2W56R into the inner mitochondrial membrane in the correct Nout-Cout topology (Nieto-Panqueva et al. 2024). The Plasmodium falciparum putative SURF1 protein can functionally replace SHY1, a COX assembly factor of complex IV of the mitochondrial electron transfer complex of Saccharomyces cerevisiae (Chellappan et al. 2021). 

Accession Number:P00401
Protein Name:Cytochrome c oxidase subunit 1
Length:534
Molecular Weight:58798.00
Species:Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) [559292]
Number of TMSs:12
Location1 / Topology2 / Orientation3: Mitochondrion inner membrane1 / Multi-pass membrane protein2
Substrate

Cross database links:

Entrez Gene ID: 854598   
Pfam: PF00115   
KEGG: sce:Q0045   

Gene Ontology

GO:0016021 C:integral to membrane
GO:0005751 C:mitochondrial respiratory chain complex IV
GO:0004129 F:cytochrome-c oxidase activity
GO:0009055 F:electron carrier activity
GO:0020037 F:heme binding
GO:0009060 P:aerobic respiration
GO:0006123 P:mitochondrial electron transport, cytochrome c to oxygen

References (4)

[1] “Assembly of the mitochondrial membrane system. Structure and nucleotide sequence of the gene coding for subunit 1 of yeast cytochrome oxidase.”  Bonitz S.G.et.al.   6254986
[2] “The complete sequence of the mitochondrial genome of Saccharomyces cerevisiae.”  Foury F.et.al.   9872396
[3] “Sequence of the yeast mitochondrial OX13/OL12 promoter region.”  Seraphin B.et.al.   2664712
[4] “Kinetic properties and ligand binding of the eleven-subunit cytochrome-c oxidase from Saccharomyces cerevisiae isolated with a novel large-scale purification method.”  Geier B.M.et.al.   7851399
Structure:
6GIQ   6HU9   6T0B   6T15   6YMX   6YMY     

External Searches:

Analyze:

Predict TMSs (Predict number of transmembrane segments)
Window Size: Angle:  
FASTA formatted sequence 
1:	MVQRWLYSTN AKDIAVLYFM LAIFSGMAGT AMSLIIRLEL AAPGSQYLHG NSQLFNVLVV 
61:	GHAVLMIFFL VMPALIGGFG NYLLPLMIGA TDTAFPRINN IAFWVLPMGL VCLVTSTLVE 
121:	SGAGTGWTVY PPLSSIQAHS GPSVDLAIFA LHLTSISSLL GAINFIVTTL NMRTNGMTMH 
181:	KLPLFVWSIF ITAFLLLLSL PVLSAGITML LLDRNFNTSF FEVSGGGDPI LYEHLFWFFG 
241:	HPEVYILIIP GFGIISHVVS TYSKKPVFGE ISMVYAMASI GLLGFLVWSH HMYIVGLDAD 
301:	TRAYFTSATM IIAIPTGIKI FSWLATIHGG SIRLATPMLY AIAFLFLFTM GGLTGVALAN 
361:	ASLDVAFHDT YYVVGHFHYV LSMGAIFSLF AGYYYWSPQI LGLNYNEKLA QIQFWLIFIG 
421:	ANVIFFPMHF LGINGMPRRI PDYPDAFAGW NYVASIGSFI ATLSLFLFIY ILYDQLVNGL 
481:	NNKVNNKSVI YNKAPDFVES NTIFNLNTVK SSSIEFLLTS PPAVHSFNTP AVQS