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3.D.4.11.1
Cytochrome oxidase (Cox or CcO).  Reversible hydration-level changes of the cavity can be a key factor that regulates the branching of proton transfer events and therefore contributes to the vectorial efficiency of proton transport (Son et al. 2017). Cox16 is required for the assembly of the mitochondrial cytochrome c oxidase (respiratory chain complex IV (CIV)), possibly by promoting the insertion of copper into the active site of cytochrome c oxidase subunit II (MT-CO2/COX2) (Cerqua et al. 2018; Aich et al. 2018). Lipid composition affects the efficiency of the functional reconstitution of the cytochrome c oxidase (Hugentobler et al. 2020). The DeepCys program has been used to predict the functions of cysteine residues in Cox2 (Nallapareddy et al. 2021).

Accession Number:P00403
Protein Name:CoxII aka MT-CO2
Length:227
Molecular Weight:25565.00
Species:Homo sapiens (Human) [9606]
Number of TMSs:2
Location1 / Topology2 / Orientation3: Mitochondrion inner membrane1 / Multi-pass membrane protein2
Substrate hydron

Cross database links:

RefSeq: YP_003024029.1   
Entrez Gene ID: 4513   
Pfam: PF00116    PF02790   
OMIM: 220110  phenotype
516040  gene
KEGG: hsa:4513   

Gene Ontology

GO:0016021 C:integral to membrane
GO:0005743 C:mitochondrial inner membrane
GO:0070469 C:respiratory chain
GO:0005507 F:copper ion binding
GO:0004129 F:cytochrome-c oxidase activity
GO:0009055 F:electron carrier activity
GO:0020037 F:heme binding
GO:0006123 P:mitochondrial electron transport, cytochrom...
GO:0006810 P:transport

References (12)

[1] “Sequence and organization of the human mitochondrial genome.”  Anderson S.et.al.   7219534
[2] “Nucleotide sequence of human mitochondrial cytochrome c oxidase II cDNA.”  Power M.D.et.al.   2550900
[3] “A different genetic code in human mitochondria.”  Barrell B.G.et.al.   226894
[4] “Recent African origin of modern humans revealed by complete sequences of hominoid mitochondrial DNAs.”  Horai S.et.al.   7530363
[5] “Mitochondrial COII sequences and modern human origins.”  Ruvolo M.et.al.   8277847
[6] “Lineage-specific selection in human mtDNA: lack of polymorphisms in a segment of MTND5 gene in haplogroup J.”  Moilanen J.S.et.al.   12949126
[7] “Mitochondrial genome variation and the origin of modern humans.”  Ingman M.et.al.   11130070
[8] “Mitochondrial genome variation and evolutionary history of Australian and New Guinean aborigines.”  Ingman M.et.al.   12840039
[9] “Single nucleotide polymorphisms over the entire mtDNA genome that increase the power of forensic testing in Caucasians.”  Coble M.D.et.al.   14760490
[10] “Normal variants of human mitochondrial DNA and translation products: the building of a reference data base.”  Marzuki S.et.al.   1757091
[11] “Somatic mutations of the mitochondrial genome in human colorectal tumours.”  Polyak K.et.al.   9806551
[12] “A missense mutation of cytochrome oxidase subunit II causes defective assembly and myopathy.”  Rahman S.et.al.   10486321
Structure:
3VRJ   5Z62     

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Predict TMSs (Predict number of transmembrane segments)
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FASTA formatted sequence 
1:	MAHAAQVGLQ DATSPIMEEL ITFHDHALMI IFLICFLVLY ALFLTLTTKL TNTNISDAQE 
61:	METVWTILPA IILVLIALPS LRILYMTDEV NDPSLTIKSI GHQWYWTYEY TDYGGLIFNS 
121:	YMLPPLFLEP GDLRLLDVDN RVVLPIEAPI RMMITSQDVL HSWAVPTLGL KTDAIPGRLN 
181:	QTTFTATRPG VYYGQCSEIC GANHSFMPIV LELIPLKIFE MGPVFTL