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3.D.4.8.1
Cytochrome oxidase (Cox).  The factors limiting the allotopic production of the Cox2 subunit of yeast cytochrome c oxidase have been discovered (Nieto-Panqueva et al. 2024). The biogenesis pathway followed by the allotopically produced Cox2 subunit based on the participation of the 2 different structural/functional forms of the TIM23 translocon, TIM23MOTOR and TIM23SORT must follow a concerted and sequential mode of action to insert Cox2W56R into the inner mitochondrial membrane in the correct Nout-Cout topology (Nieto-Panqueva et al. 2024). The Plasmodium falciparum putative SURF1 protein can functionally replace SHY1, a COX assembly factor of complex IV of the mitochondrial electron transfer complex of Saccharomyces cerevisiae (Chellappan et al. 2021). 

Accession Number:P00410
Protein Name:Cytochrome c oxidase subunit 2
Length:251
Molecular Weight:28567.00
Species:Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) [559292]
Number of TMSs:2
Location1 / Topology2 / Orientation3: Mitochondrion inner membrane1 / Multi-pass membrane protein2
Substrate

Cross database links:

DIP: DIP-7592N DIP-7592N
Entrez Gene ID: 854622   
Pfam: PF00116    PF02790   
KEGG: sce:Q0250   

Gene Ontology

GO:0016021 C:integral to membrane
GO:0005751 C:mitochondrial respiratory chain complex IV
GO:0005507 F:copper ion binding
GO:0004129 F:cytochrome-c oxidase activity
GO:0009055 F:electron carrier activity
GO:0020037 F:heme binding
GO:0005515 F:protein binding
GO:0009060 P:aerobic respiration
GO:0006123 P:mitochondrial electron transport, cytochrome c to oxygen

References (6)

[1] “Assembly of the mitochondrial membrane system. DNA sequence of subunit 2 of yeast cytochrome oxidase.”  Coruzzi G.et.al.   225327
[2] “Five TGA 'stop' codons occur within the translated sequence of the yeast mitochondrial gene for cytochrome c oxidase subunit II.”  Fox T.D.et.al.   230513
[3] “The complete sequence of the mitochondrial genome of Saccharomyces cerevisiae.”  Foury F.et.al.   9872396
[4] “Isolation and characterization of a yeast strain carrying a mutation in the mitochondrial promoter for COX2.”  Cameron V.L.et.al.   2547760
[5] “Use of the UGA terminator as a tryptophan codon in yeast mitochondria.”  Macino G.et.al.   226981
[6] “Kinetic properties and ligand binding of the eleven-subunit cytochrome-c oxidase from Saccharomyces cerevisiae isolated with a novel large-scale purification method.”  Geier B.M.et.al.   7851399
Structure:
6GIQ   6HU9   6T0B   6T15   6YMX   6YMY     

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Predict TMSs (Predict number of transmembrane segments)
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FASTA formatted sequence 
1:	MLDLLRLQLT TFIMNDVPTP YACYFQDSAT PNQEGILELH DNIMFYLLVI LGLVSWMLYT 
61:	IVMTYSKNPI AYKYIKHGQT IEVIWTIFPA VILLIIAFPS FILLYLCDEV ISPAMTIKAI 
121:	GYQWYWKYEY SDFINDSGET VEFESYVIPD ELLEEGQLRL LDTDTSMVVP VDTHIRFVVT 
181:	AADVIHDFAI PSLGIKVDAT PGRLNQVSAL IQREGVFYGA CSELCGTGHA NMPIKIEAVS 
241:	LPKFLEWLNE Q