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3.D.4.11.1
Cytochrome oxidase (Cox or CcO).  Reversible hydration-level changes of the cavity can be a key factor that regulates the branching of proton transfer events and therefore contributes to the vectorial efficiency of proton transport (Son et al. 2017). Cox16 is required for the assembly of the mitochondrial cytochrome c oxidase (respiratory chain complex IV (CIV)), possibly by promoting the insertion of copper into the active site of cytochrome c oxidase subunit II (MT-CO2/COX2) (Cerqua et al. 2018; Aich et al. 2018). Lipid composition affects the efficiency of the functional reconstitution of the cytochrome c oxidase (Hugentobler et al. 2020). The DeepCys program has been used to predict the functions of cysteine residues in Cox2 (Nallapareddy et al. 2021).

Accession Number:P00414
Protein Name:CoxIII aka MT-CO3
Length:261
Molecular Weight:29951.00
Species:Homo sapiens (Human) [9606]
Number of TMSs:6
Location1 / Topology2 / Orientation3: Mitochondrion inner membrane1 / Multi-pass membrane protein2
Substrate hydron

Cross database links:

RefSeq: YP_003024032.1   
Entrez Gene ID: 4514   
Pfam: PF00510   
OMIM: 220110  phenotype
516050  gene
535000  phenotype
550500  phenotype
KEGG: hsa:4514   

Gene Ontology

GO:0016021 C:integral to membrane
GO:0005743 C:mitochondrial inner membrane
GO:0004129 F:cytochrome-c oxidase activity
GO:0006123 P:mitochondrial electron transport, cytochrom...

References (7)

[1] “Sequence and organization of the human mitochondrial genome.”  Anderson S.et.al.   7219534
[2] “In situ origin of deep rooting lineages of mitochondrial Macrohaplogroup 'M' in India.”  Thangaraj K.et.al.   16776823
[3] “Normal variants of human mitochondrial DNA and translation products: the building of a reference data base.”  Marzuki S.et.al.   1757091
[4] “Cytochrome c oxidase mutations in Leber hereditary optic neuropathy.”  Johns D.R.et.al.   8240356
[5] “A new mutation associated with MELAS is located in a mitochondrial DNA polypeptide-coding gene.”  Manfredi G.et.al.   7496173
[6] “A microdeletion in cytochrome c oxidase (COX) subunit III associated with COX deficiency and recurrent myoglobinuria.”  Keightley J.A.et.al.   8630495
[7] “Automating the identification of DNA variations using quality-based fluorescence re-sequencing: analysis of the human mitochondrial genome.”  Rieder M.J.et.al.   9461455
Structure:
5Z62     

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Predict TMSs (Predict number of transmembrane segments)
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FASTA formatted sequence 
1:	MTHQSHAYHM VKPSPWPLTG ALSALLMTSG LAMWFHFHSM TLLMLGLLTN TLTMYQWWRD 
61:	VTRESTYQGH HTPPVQKGLR YGMILFITSE VFFFAGFFWA FYHSSLAPTP QLGGHWPPTG 
121:	ITPLNPLEVP LLNTSVLLAS GVSITWAHHS LMENNRNQMI QALLITILLG LYFTLLQASE 
181:	YFESPFTISD GIYGSTFFVA TGFHGLHVII GSTFLTICFI RQLMFHFTSK HHFGFEAAAW 
241:	YWHFVDVVWL FLYVSIYWWG S