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3.D.4.8.1
Cytochrome oxidase (Cox).  The factors limiting the allotopic production of the Cox2 subunit of yeast cytochrome c oxidase have been discovered (Nieto-Panqueva et al. 2024). The biogenesis pathway followed by the allotopically produced Cox2 subunit based on the participation of the 2 different structural/functional forms of the TIM23 translocon, TIM23MOTOR and TIM23SORT must follow a concerted and sequential mode of action to insert Cox2W56R into the inner mitochondrial membrane in the correct Nout-Cout topology (Nieto-Panqueva et al. 2024). The Plasmodium falciparum putative SURF1 protein can functionally replace SHY1, a COX assembly factor of complex IV of the mitochondrial electron transfer complex of Saccharomyces cerevisiae (Chellappan et al. 2021). 

Accession Number:P00420
Protein Name:Cytochrome c oxidase subunit 3
Length:269
Molecular Weight:30360.00
Species:Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) [559292]
Number of TMSs:7
Location1 / Topology2 / Orientation3: Mitochondrion inner membrane1 / Multi-pass membrane protein2
Substrate

Cross database links:

DIP: DIP-8133N DIP-8133N
Entrez Gene ID: 854627   
Pfam: PF00510   
KEGG: sce:Q0275   

Gene Ontology

GO:0016021 C:integral to membrane
GO:0005751 C:mitochondrial respiratory chain complex IV
GO:0004129 F:cytochrome-c oxidase activity
GO:0019646 P:aerobic electron transport chain
GO:0006123 P:mitochondrial electron transport, cytochrome c to oxygen

References (4)

[1] “Assembly of the mitochondrial membrane system. Sequence of the oxi 2 gene of yeast mitochondrial DNA.”  Thalenfeld B.E.et.al.   6248512
[2] “The primary structure of the mitochondrial genome of Saccharomyces cerevisiae -- a review.”  de Zamaroczy M.et.al.   3549452
[3] “The complete sequence of the mitochondrial genome of Saccharomyces cerevisiae.”  Foury F.et.al.   9872396
[4] “Kinetic properties and ligand binding of the eleven-subunit cytochrome-c oxidase from Saccharomyces cerevisiae isolated with a novel large-scale purification method.”  Geier B.M.et.al.   7851399
Structure:
6GIQ   6HU9   6T0B   6T15   6YMX   6YMY     

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Predict TMSs (Predict number of transmembrane segments)
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FASTA formatted sequence 
1:	MTHLERSRHQ QHPFHMVMPS PWPIVVSFAL LSLALSTALT MHGYIGNMNM VYLALFVLLT 
61:	SSILWFRDIV AEATYLGDHT MAVRKGINLG FLMFVLSEVL IFAGLFWAYF HSAMSPDVTL 
121:	GACWPPVGIE AVQPTELPLL NTIILLSSGA TVTYSHHALI AGNRNKALSG LLITFWLIVI 
181:	FVTCQYIEYT NAAFTISDGV YGSVFYAGTG LHFLHMVMLA AMLGVNYWRM RNYHLTAGHH 
241:	VGYETTIIYT HVLDVIWLFL YVVFYWWGV