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3.D.4.8.1
Cytochrome oxidase (Cox).  The factors limiting the allotopic production of the Cox2 subunit of yeast cytochrome c oxidase have been discovered (Nieto-Panqueva et al. 2024). The biogenesis pathway followed by the allotopically produced Cox2 subunit based on the participation of the 2 different structural/functional forms of the TIM23 translocon, TIM23MOTOR and TIM23SORT must follow a concerted and sequential mode of action to insert Cox2W56R into the inner mitochondrial membrane in the correct Nout-Cout topology (Nieto-Panqueva et al. 2024). The Plasmodium falciparum putative SURF1 protein can functionally replace SHY1, a COX assembly factor of complex IV of the mitochondrial electron transfer complex of Saccharomyces cerevisiae (Chellappan et al. 2021). 

Accession Number:P00424
Protein Name:Cytochrome c oxidase polypeptide 5A, mitochondrial
Length:153
Molecular Weight:17140.00
Species:Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) [559292]
Number of TMSs:1
Location1 / Topology2 / Orientation3: Mitochondrion inner membrane1
Substrate

Cross database links:

DIP: DIP-6820N DIP-6820N
Entrez Gene ID: 855675   
Pfam: PF02936   
KEGG: sce:YNL052W   

Gene Ontology

GO:0005751 C:mitochondrial respiratory chain complex IV
GO:0004129 F:cytochrome-c oxidase activity
GO:0006123 P:mitochondrial electron transport, cytochrome c to oxygen

References (12)

[1] “Primary structure of a gene for subunit V of the cytochrome c oxidase from Saccharomyces cerevisiae.”  Seraphin B.et.al.   2836092
[2] “Cloning and characterization of the yeast nuclear gene for subunit 5 of cytochrome oxidase.”  Koerner T.J.et.al.   2991248
[3] “Structural analysis of two genes encoding divergent forms of yeast cytochrome c oxidase subunit V.”  Cumsky M.G.et.al.   2824989
[4] “The sequence of a 44 420 bp fragment located on the left arm of chromosome XIV from Saccharomyces cerevisiae.”  Bergez P.et.al.   8533472
[5] “”  Bergez P.et.al.   8904343
[6] “The nucleotide sequence of Saccharomyces cerevisiae chromosome XIV and its evolutionary implications.”  Philippsen P.et.al.   9169873
[7] “Approaching a complete repository of sequence-verified protein-encoding clones for Saccharomyces cerevisiae.”  Hu Y.et.al.   17322287
[8] “Two nonidentical forms of subunit V are functional in yeast cytochrome c oxidase.”  Cumsky M.G.et.al.   2986105
[9] “The nuclear-coded subunits of yeast cytochrome c oxidase. III. Identification of homologous subunits in yeast, bovine heart, and Neurospora crassa cytochrome c oxidases.”  Power S.D.et.al.   6327686
[10] “Import of proteins into mitochondria. Isolated yeast mitochondria and a solubilized matrix protease correctly process cytochrome c oxidase subunit V precursor at the NH2 terminus.”  Cerletti N.et.al.   6300105
[11] “Kinetic properties and ligand binding of the eleven-subunit cytochrome-c oxidase from Saccharomyces cerevisiae isolated with a novel large-scale purification method.”  Geier B.M.et.al.   7851399
[12] “Global analysis of protein expression in yeast.”  Ghaemmaghami S.et.al.   14562106
Structure:
6GIQ   6HU9   6YMX   6YMY     

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Predict TMSs (Predict number of transmembrane segments)
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FASTA formatted sequence 
1:	MLRNTFTRAG GLSRITSVRF AQTHALSNAA VMDLQSRWEN MPSTEQQDIV SKLSERQKLP 
61:	WAQLTEPEKQ AVWYISYGEW GPRRPVLNKG DSSFIAKGVA AGLLFSVGLF AVVRMAGGQD 
121:	AKTMNKEWQL KSDEYLKSKN ANPWGGYSQV QSK