Search TCDB: (?)
TCDB is operated by the Saier Lab Bioinformatics Group
« See all members of the family


3.D.4.8.1
Cytochrome oxidase (Cox).  The factors limiting the allotopic production of the Cox2 subunit of yeast cytochrome c oxidase have been discovered (Nieto-Panqueva et al. 2024). The biogenesis pathway followed by the allotopically produced Cox2 subunit based on the participation of the 2 different structural/functional forms of the TIM23 translocon, TIM23MOTOR and TIM23SORT must follow a concerted and sequential mode of action to insert Cox2W56R into the inner mitochondrial membrane in the correct Nout-Cout topology (Nieto-Panqueva et al. 2024). The Plasmodium falciparum putative SURF1 protein can functionally replace SHY1, a COX assembly factor of complex IV of the mitochondrial electron transfer complex of Saccharomyces cerevisiae (Chellappan et al. 2021). 

Accession Number:P00425
Protein Name:Cytochrome c oxidase polypeptide 5B, mitochondrial
Length:151
Molecular Weight:17197.00
Species:Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) [559292]
Number of TMSs:1
Location1 / Topology2 / Orientation3: Mitochondrion inner membrane1
Substrate

Cross database links:

DIP: DIP-4709N DIP-4709N
Entrez Gene ID: 854695   
Pfam: PF02936   
KEGG: sce:YIL111W   

Gene Ontology

GO:0005751 C:mitochondrial respiratory chain complex IV
GO:0004129 F:cytochrome-c oxidase activity
GO:0006123 P:mitochondrial electron transport, cytochrome c to oxygen

References (6)

[1] “Structural analysis of two genes encoding divergent forms of yeast cytochrome c oxidase subunit V.”  Cumsky M.G.et.al.   2824989
[2] “The nucleotide sequence of Saccharomyces cerevisiae chromosome IX.”  Churcher C.M.et.al.   9169870
[3] “Splicing of a yeast intron containing an unusual 5' junction sequence.”  Hodge M.R.et.al.   2548089
[4] “Two nonidentical forms of subunit V are functional in yeast cytochrome c oxidase.”  Cumsky M.G.et.al.   2986105
[5] “Kinetic properties and ligand binding of the eleven-subunit cytochrome-c oxidase from Saccharomyces cerevisiae isolated with a novel large-scale purification method.”  Geier B.M.et.al.   7851399
[6] “Global analysis of protein expression in yeast.”  Ghaemmaghami S.et.al.   14562106
Structure:
6T0B   6T15     

External Searches:

Analyze:

Predict TMSs (Predict number of transmembrane segments)
Window Size: Angle:  
FASTA formatted sequence 
1:	MLRTSLTKGA RLTGTRFVQT KALSKATLTD LPERWENMPN LEQKEIADNL TERQKLPWKT 
61:	LNNEEIKAAW YISYGEWGPR RPVHGKGDVA FITKGVFLGL GISFGLFGLV RLLANPETPK 
121:	TMNREWQLKS DEYLKSKNAN PWGGYSQVQS K