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3.D.4.8.1
Cytochrome oxidase (Cox).  The factors limiting the allotopic production of the Cox2 subunit of yeast cytochrome c oxidase have been discovered (Nieto-Panqueva et al. 2024). The biogenesis pathway followed by the allotopically produced Cox2 subunit based on the participation of the 2 different structural/functional forms of the TIM23 translocon, TIM23MOTOR and TIM23SORT must follow a concerted and sequential mode of action to insert Cox2W56R into the inner mitochondrial membrane in the correct Nout-Cout topology (Nieto-Panqueva et al. 2024). The Plasmodium falciparum putative SURF1 protein can functionally replace SHY1, a COX assembly factor of complex IV of the mitochondrial electron transfer complex of Saccharomyces cerevisiae (Chellappan et al. 2021). 

Accession Number:P00427
Protein Name:Cytochrome c oxidase subunit 6, mitochondrial
Length:148
Molecular Weight:17342.00
Species:Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) [559292]
Location1 / Topology2 / Orientation3: Mitochondrion inner membrane1
Substrate

Cross database links:

DIP: DIP-6606N DIP-6606N
Entrez Gene ID: 856448   
Pfam: PF02284   
KEGG: sce:YHR051W   

Gene Ontology

GO:0005751 C:mitochondrial respiratory chain complex IV
GO:0004129 F:cytochrome-c oxidase activity
GO:0046872 F:metal ion binding
GO:0006123 P:mitochondrial electron transport, cytochrome c to oxygen

References (7)

[1] “Isolation and sequence of the structural gene for cytochrome c oxidase subunit VI from Saccharomyces cerevisiae.”  Wright R.M.et.al.   6210289
[2] “Complete nucleotide sequence of Saccharomyces cerevisiae chromosome VIII.”  Johnston M.et.al.   8091229
[3] “Approaching a complete repository of sequence-verified protein-encoding clones for Saccharomyces cerevisiae.”  Hu Y.et.al.   17322287
[4] “Organization and expression of the COX6 genetic locus in Saccharomyces cerevisiae: multiple mRNAs with different 3' termini are transcribed from COX6 and regulated differentially.”  Wright R.M.et.al.   2537949
[5] “The amino acid sequence of cytochrome c oxidase subunit VI from Saccharomyces cerevisiae.”  Gregor I.et.al.   6290493
[6] “Kinetic properties and ligand binding of the eleven-subunit cytochrome-c oxidase from Saccharomyces cerevisiae isolated with a novel large-scale purification method.”  Geier B.M.et.al.   7851399
[7] “Global analysis of protein expression in yeast.”  Ghaemmaghami S.et.al.   14562106
Structure:
6GIQ   6HU9   6T0B   6T15   6YMX   6YMY     

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Predict TMSs (Predict number of transmembrane segments)
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FASTA formatted sequence 
1:	MLSRAIFRNP VINRTLLRAR PGAYHATRLT KNTFIQSRKY SDAHDEETFE EFTARYEKEF 
61:	DEAYDLFEVQ RVLNNCFSYD LVPAPAVIEK ALRAARRVND LPTAIRVFEA LKYKVENEDQ 
121:	YKAYLDELKD VRQELGVPLK EELFPSSS