9.A.75.1.1
The MHCII complex of three proteins, DQ alpha-1, DQ beta-1 (which form a heterodimer) and a CD75 homotrimer that together form a nanomer with 3 copies of the MHCII dimer. It transports antigenic peptides to the cell surface (Wosen et al. 2018). The structure, topology, and dynamics of membrane-inserted polypeptides and lipids have been examined by solid-state NMR spectroscopy, specifically with respect to the transmembrane domains of the DQ Beta-1 subunit of the MHC II receptor and the COP I protein, p24 (Salnikov et al. 2019).
|
| Accession Number: | P01909 |
|---|
| Protein Name: | HLA class II histocompatibility antigen, DQ alpha 1 chain |
|---|
| Length: | 254 |
|---|
| Molecular Weight: | 27805.00 |
|---|
| Species: | Homo sapiens (Human) [9606] |
|---|
| Number of TMSs: | 1 |
|---|
| Location1 / Topology2 / Orientation3: |
Cell membrane1 / Single-pass type I membrane protein2 |
|---|
| Substrate |
peptide |
|---|
1: MILNKALMLG ALALTTVMSP CGGEDIVADH VASYGVNLYQ SYGPSGQYTH EFDGDEQFYV
61: DLGRKETVWC LPVLRQFRFD PQFALTNIAV LKHNLNSLIK RSNSTAATNE VPEVTVFSKS
121: PVTLGQPNIL ICLVDNIFPP VVNITWLSNG HSVTEGVSET SFLSKSDHSF FKISYLTLLP
181: SAEESYDCKV EHWGLDKPLL KHWEPEIPAP MSELTETVVC ALGLSVGLVG IVVGTVFIIR
241: GLRSVGASRH QGPL