9.A.75.1.1
The MHCII complex of three proteins, DQ alpha-1, DQ beta-1 (which form a heterodimer) and a CD75 homotrimer that together form a nanomer with 3 copies of the MHCII dimer. It transports antigenic peptides to the cell surface (Wosen et al. 2018). The structure, topology, and dynamics of membrane-inserted polypeptides and lipids have been examined by solid-state NMR spectroscopy, specifically with respect to the transmembrane domains of the DQ Beta-1 subunit of the MHC II receptor and the COP I protein, p24 (Salnikov et al. 2019).
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| Accession Number: | P01920 |
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| Protein Name: | HLA class II histocompatibility antigen, DQ beta 1 chain |
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| Length: | 261 |
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| Molecular Weight: | 29991.00 |
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| Species: | Homo sapiens (Human) [9606] |
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| Number of TMSs: | 2 |
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| Location1 / Topology2 / Orientation3: |
Cell membrane1 / Single-pass type I membrane protein2 |
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| Substrate |
peptide |
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1: MSWKKALRIP GGLRAATVTL MLAMLSTPVA EGRDSPEDFV YQFKAMCYFT NGTERVRYVT
61: RYIYNREEYA RFDSDVEVYR AVTPLGPPDA EYWNSQKEVL ERTRAELDTV CRHNYQLELR
121: TTLQRRVEPT VTISPSRTEA LNHHNLLVCS VTDFYPAQIK VRWFRNDQEE TTGVVSTPLI
181: RNGDWTFQIL VMLEMTPQHG DVYTCHVEHP SLQNPITVEW RAQSESAQSK MLSGIGGFVL
241: GLIFLGLGLI IHHRSQKGLL H