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3.D.4.8.1
Cytochrome oxidase (Cox).  The factors limiting the allotopic production of the Cox2 subunit of yeast cytochrome c oxidase have been discovered (Nieto-Panqueva et al. 2024). The biogenesis pathway followed by the allotopically produced Cox2 subunit based on the participation of the 2 different structural/functional forms of the TIM23 translocon, TIM23MOTOR and TIM23SORT must follow a concerted and sequential mode of action to insert Cox2W56R into the inner mitochondrial membrane in the correct Nout-Cout topology (Nieto-Panqueva et al. 2024). The Plasmodium falciparum putative SURF1 protein can functionally replace SHY1, a COX assembly factor of complex IV of the mitochondrial electron transfer complex of Saccharomyces cerevisiae (Chellappan et al. 2021). 

Accession Number:P04037
Protein Name:Cytochrome c oxidase subunit 4, mitochondrial
Length:155
Molecular Weight:17143.00
Species:Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) [559292]
Location1 / Topology2 / Orientation3: Mitochondrion inner membrane1
Substrate

Cross database links:

DIP: DIP-2763N DIP-2763N
Entrez Gene ID: 852688   
Pfam: PF01215   
KEGG: sce:YGL187C   

Gene Ontology

GO:0005751 C:mitochondrial respiratory chain complex IV
GO:0004129 F:cytochrome-c oxidase activity
GO:0008270 F:zinc ion binding
GO:0009060 P:aerobic respiration
GO:0006123 P:mitochondrial electron transport, cytochrome c to oxygen

References (9)

[1] “Subunit IV of yeast cytochrome c oxidase: cloning and nucleotide sequencing of the gene and partial amino acid sequencing of the mature protein.”  Maarse A.C.et.al.   6098449
[2] “Sequencing of a 40.5 kb fragment located on the left arm of chromosome VII from Saccharomyces cerevisiae.”  Coglievina M.et.al.   9046087
[3] “The nucleotide sequence of Saccharomyces cerevisiae chromosome VII.”  Tettelin H.et.al.   9169869
[4] “High-density yeast-tiling array reveals previously undiscovered introns and extensive regulation of meiotic splicing.”  Juneau K.et.al.   17244705
[5] “The untranslated leader of nuclear COX4 gene of Saccharomyces cerevisiae contains an intron.”  Schneider J.C.et.al.   3033605
[6] “The nuclear-coded subunits of yeast cytochrome c oxidase. III. Identification of homologous subunits in yeast, bovine heart, and Neurospora crassa cytochrome c oxidases.”  Power S.D.et.al.   6327686
[7] “Kinetic properties and ligand binding of the eleven-subunit cytochrome-c oxidase from Saccharomyces cerevisiae isolated with a novel large-scale purification method.”  Geier B.M.et.al.   7851399
[8] “Profiling phosphoproteins of yeast mitochondria reveals a role of phosphorylation in assembly of the ATP synthase.”  Reinders J.et.al.   17761666
[9] “Crystal structures of mitochondrial processing peptidase reveal the mode for specific cleavage of import signal sequences.”  Taylor A.B.et.al.   11470436
Structure:
1HR8   2ODX   2ODX   6GIQ   6HU9   6T0B   6T15   6YMX   6YMY      [...more]

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FASTA formatted sequence 
1:	MLSLRQSIRF FKPATRTLCS SRYLLQQKPV VKTAQNLAEV NGPETLIGPG AKEGTVPTDL 
61:	DQETGLARLE LLGKLEGIDV FDTKPLDSSR KGTMKDPIII ESYDDYRYVG CTGSPAGSHT 
121:	IMWLKPTVNE VARCWECGSV YKLNPVGVPN DDHHH