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3.D.4.8.1
Cytochrome oxidase (Cox).  The factors limiting the allotopic production of the Cox2 subunit of yeast cytochrome c oxidase have been discovered (Nieto-Panqueva et al. 2024). The biogenesis pathway followed by the allotopically produced Cox2 subunit based on the participation of the 2 different structural/functional forms of the TIM23 translocon, TIM23MOTOR and TIM23SORT must follow a concerted and sequential mode of action to insert Cox2W56R into the inner mitochondrial membrane in the correct Nout-Cout topology (Nieto-Panqueva et al. 2024). The Plasmodium falciparum putative SURF1 protein can functionally replace SHY1, a COX assembly factor of complex IV of the mitochondrial electron transfer complex of Saccharomyces cerevisiae (Chellappan et al. 2021). 

Accession Number:P04039
Protein Name:Cytochrome c oxidase polypeptide VIII, mitochondrial
Length:78
Molecular Weight:8907.00
Species:Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) [559292]
Number of TMSs:1
Location1 / Topology2 / Orientation3: Mitochondrion inner membrane1
Substrate

Cross database links:

DIP: DIP-5445N DIP-5445N
Entrez Gene ID: 851111   
Pfam: PF02935   
KEGG: sce:YLR395C   

Gene Ontology

GO:0005751 C:mitochondrial respiratory chain complex IV
GO:0004129 F:cytochrome-c oxidase activity
GO:0006123 P:mitochondrial electron transport, cytochrome c to oxygen

References (6)

[1] “COX8, the structural gene for yeast cytochrome c oxidase subunit VIII. DNA sequence and gene disruption indicate that subunit VIII is required for maximal levels of cellular respiration and is derived from a precursor which is extended at both its NH2 and COOH termini.”  Patterson T.E.et.al.   3023386
[2] “The nucleotide sequence of Saccharomyces cerevisiae chromosome XII.”  Johnston M.et.al.   9169871
[3] “Approaching a complete repository of sequence-verified protein-encoding clones for Saccharomyces cerevisiae.”  Hu Y.et.al.   17322287
[4] “The nuclear-coded subunits of yeast cytochrome c oxidase. II. The amino acid sequence of subunit VIII and a model for its disposition in the inner mitochondrial membrane.”  Power S.D.et.al.   6327685
[5] “Kinetic properties and ligand binding of the eleven-subunit cytochrome-c oxidase from Saccharomyces cerevisiae isolated with a novel large-scale purification method.”  Geier B.M.et.al.   7851399
[6] “Global analysis of protein expression in yeast.”  Ghaemmaghami S.et.al.   14562106
Structure:
6GIQ   6HU9   6T0B   6T15   6YMX   6YMY     

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Predict TMSs (Predict number of transmembrane segments)
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FASTA formatted sequence 
1:	MLCQQMIRTT AKRSSNIMTR PIIMKRSVHF KDGVYENIPF KVKGRKTPYA LSHFGFFAIG 
61:	FAVPFVACYV QLKKSGAF