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|---|---|
| Accession Number: | P04977 |
| Protein Name: | PTX S1 |
| Length: | 269 |
| Molecular Weight: | 29974.00 |
| Species: | Bordetella pertussis [520] |
| Number of TMSs: | 1 |
| Location1 / Topology2 / Orientation3: | Secreted1 |
| Substrate | toxin |
Cross database links:
| RefSeq: | NP_882282.1 |
|---|---|
| Entrez Gene ID: | 2665068 |
| Pfam: | PF02917 |
| BioCyc: | BPER257313:BP3783-MONOMER |
| KEGG: | bpe:BP3783 |
Gene Ontology
GO:0005576
C:extracellular region
GO:0003950
F:NAD+ ADP-ribosyltransferase activity
GO:0009405
P:pathogenesis
| |
References (19)[1] “Cloning and sequencing of the pertussis toxin genes: operon structure and gene duplication.” Nicosia A.et.al. 2873570 [2] “Pertussis toxin gene: nucleotide sequence and genetic organization.” Locht C.et.al. 3704651 [3] “A unique sequence of the Bordetella pertussis toxin operon.” Loosmore S.M.et.al. 2554254 [4] “Polymorphism in the Bordetella pertussis virulence factors P.69/pertactin and pertussis toxin in The Netherlands: temporal trends and evidence for vaccine-driven evolution.” Mooi F.R.et.al. 9453625 [5] “Intranasal murine model of Bordetella pertussis infection: II. Sequence variation and protection induced by a tricomponent acellular vaccine.” Boursaux-Eude C.et.al. 10418915 [6] “Temporal trends in circulating Bordetella pertussis strains in Australia.” Poynten M.et.al. 15061492 [7] “Comparative analysis of the genome sequences of Bordetella pertussis, Bordetella parapertussis and Bordetella bronchiseptica.” Parkhill J.et.al. 12910271 [8] “Identification of a region in the S1 subunit of pertussis toxin that is required for enzymatic activity and that contributes to the formation of a neutralizing antigenic determinant.” Cieplak W.et.al. 2455296 [9] “Identification of an active-site residue in subunit S1 of pertussis toxin by photocrosslinking to NAD.” Cockle S.A.et.al. 2737291 [10] “Role of tryptophan 26 in the NAD glycohydrolase reaction of the S-1 subunit of pertussis toxin.” Cortina G.et.al. 2551899 [11] “Further analysis of the sequence of the S1 subunit of pertussis toxin.” Pizza M.et.al. 1997420 [12] “A proposed mechanism of ADP-ribosylation catalyzed by the pertussis toxin S1 subunit.” Locht C.et.al. 8527486 [13] “Synergistic binding of RNA polymerase and BvgA phosphate to the pertussis toxin promoter of Bordetella pertussis.” Boucher P.E.et.al. 7592424 [14] “Mutations in the S1 subunit of pertussis toxin that affect secretion.” Craig-Mylius K.A.et.al. 10678938 [15] “Membrane localization of the S1 subunit of pertussis toxin in Bordetella pertussis and implications for pertussis toxin secretion.” Farizo K.M.et.al. 11854200 | |
| Structure: | |
External Searches:
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Analyze:
| Predict TMSs (Predict number of transmembrane segments) | ||||
| FASTA formatted sequence |
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1: MRCTRAIRQT ARTGWLTWLA ILAVTAPVTS PAWADDPPAT VYRYDSRPPE DVFQNGFTAW 61: GNNDNVLDHL TGRSCQVGSS NSAFVSTSSS RRYTEVYLEH RMQEAVEAER AGRGTGHFIG 121: YIYEVRADNN FYGAASSYFE YVDTYGDNAG RILAGALATY QSEYLAHRRI PPENIRRVTR 181: VYHNGITGET TTTEYSNARY VSQQTRANPN PYTSRRSVAS IVGTLVRMAP VIGACMARQA 241: ESSEAMAAWS ERAGEAMVLV YYESIAYSF