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3.A.1.5.1
Oligopeptide porter (also takes up amino glycoside antibiotics such as kanamycin, streptomycin and neomycin as well as cell wall-derived peptides such as murein tripeptide). It transports substrate peptides of 2-5 amino acids with highest affinity for tripeptides. Also transports δ-aminolevulinic acid (ALA). [May be regulated by PTS Enzyme INtr-aspartokinase.] ATP-binding to OppDF may result in donation of peptide to OppBC and simultaneous release of OppA (Doeven et al., 2008).

Accession Number:P06202
Protein Name:OppA aka STM1746
Length:543
Molecular Weight:61292.00
Species:Salmonella typhimurium [90371]
Number of TMSs:1
Location1 / Topology2 / Orientation3: Periplasm1
Substrate oligopeptide

Cross database links:

RefSeq: NP_460705.2   
Entrez Gene ID: 1253265   
Pfam: PF00496   
BioCyc: STYP99287:STM1746-MONOMER   

Gene Ontology

GO:0042597 C:periplasmic space
GO:0005215 F:transporter activity
GO:0015833 P:peptide transport
GO:0015031 P:protein transport

References (7)

[1] “Molecular characterization of the oligopeptide permease of Salmonella typhimurium.”  Hiles I.D.et.al.   2821267
[2] “Peptide uptake by Salmonella typhimurium. The periplasmic oligopeptide-binding protein.”  Hiles I.D.et.al.   3525163
[3] “Complete genome sequence of Salmonella enterica serovar Typhimurium LT2.”  McClelland M.et.al.   11677609
[4] “The structural basis of sequence-independent peptide binding by OppA protein.”  Tame J.R.H.et.al.   8202710
[5] “The crystal structures of the oligopeptide-binding protein OppA complexed with tripeptide and tetrapeptide ligands.”  Tame J.R.H.et.al.   8747465
[6] “Relating structure to thermodynamics: the crystal structures and binding affinity of eight OppA-peptide complexes.”  Davies T.G.et.al.   10422831
[7] “Crystallographic and calorimetric analysis of peptide binding to OppA protein.”  Sleigh S.H.et.al.   10438628
Structure:
1B05   1B0H   1B1H   1B2H   1B32   1B3F   1B3G   1B3H   1B3L   1B40   [...more]

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Predict TMSs (Predict number of transmembrane segments)
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FASTA formatted sequence 
1:	MSNITKKSLI AAGILTALIA ASAATAADVP AGVQLADKQT LVRNNGSEVQ SLDPHKIEGV 
61:	PESNVSRDLF EGLLISDVEG HPSPGVAEKW ENKDFKVWTF HLRENAKWSD GTPVTAHDFV 
121:	YSWQRLADPN TASPYASYLQ YGHIANIDDI IAGKKPATDL GVKALDDHTF EVTLSEPVPY 
181:	FYKLLVHPSV SPVPKSAVEK FGDKWTQPAN IVTNGAYKLK NWVVNERIVL ERNPQYWDNA 
241:	KTVINQVTYL PISSEVTDVN RYRSGEIDMT YNNMPIELFQ KLKKEIPNEV RVDPYLCTYY 
301:	YEINNQKAPF NDVRVRTALK LALDRDIIVN KVKNQGDLPA YSYTPPYTDG AKLVEPEWFK 
361:	WSQQKRNEEA KKLLAEAGFT ADKPLTFDLL YNTSDLHKKL AIAVASIWKK NLGVNVNLEN 
421:	QEWKTFLDTR HQGTFDVARA GWCADYNEPT SFLNTMLSDS SNNTAHYKSP AFDKLIADTL 
481:	KVADDTQRSE LYAKAEQQLD KDSAIVPVYY YVNARLVKPW VGGYTGKDPL DNIYVKNLYI 
541:	IKH