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| Accession Number: | P06477 |
| Protein Name: | Envelope glycoprotein H |
| Length: | 838 |
| Molecular Weight: | 90366.00 |
| Species: | Human herpesvirus 1 (strain 17) (HHV-1) [10299] |
| Number of TMSs: | 1 |
| Location1 / Topology2 / Orientation3: | Virion membrane1 / Single-pass type I membrane protein2 |
| Substrate | molecule |
Cross database links:
| Entrez Gene ID: | 2703373 |
|---|---|
| Pfam: | PF02489 |
Gene Ontology
GO:0044175
C:host cell endosome membrane
GO:0020002
C:host cell plasma membrane
GO:0016021
C:integral to membrane
GO:0055036
C:virion membrane
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References (9)[1] “DNA sequence of the herpes simplex virus type 1 gene encoding glycoprotein gH, and identification of homologues in the genomes of varicella-zoster virus and Epstein-Barr virus.” McGeoch D.J.et.al. 3012465 [2] “The complete DNA sequence of the long unique region in the genome of herpes simplex virus type 1.” McGeoch D.J.et.al. 2839594 [3] “Determination and analysis of the DNA sequence of highly attenuated herpes simplex virus type 1 mutant HF10, a potential oncolytic virus.” Ushijima Y.et.al. 17218138 [4] “Structural and antigenic analysis of a truncated form of the herpes simplex virus glycoprotein gH-gL complex.” Peng T.et.al. 9621073 [5] “Structure-function analysis of herpes simplex virus type 1 gD and gH-gL: clues from gDgH chimeras.” Cairns T.M.et.al. 12767993 [6] “The cytoplasmic tail of Herpes simplex virus glycoprotein H binds to the tegument protein VP16 in vitro and in vivo.” Gross S.T.et.al. 14675620 [7] “Herpes simplex virus glycoproteins gB and gH function in fusion between the virion envelope and the outer nuclear membrane.” Farnsworth A.et.al. 17548810 [8] “Complexes between herpes simplex virus glycoproteins gD, gB, and gH detected in cells by complementation of split enhanced green fluorescent protein.” Avitabile E.et.al. 17670828 [9] “Bimolecular complementation reveals that glycoproteins gB and gH/gL of herpes simplex virus interact with each other during cell fusion.” Atanasiu D.et.al. 18003913
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| Structure: | |
External Searches:
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Analyze:
| Predict TMSs (Predict number of transmembrane segments) | ||||
| FASTA formatted sequence |
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1: MGNGLWFVGV IILGVAWGQV HDWTEQTDPW FLDGLGMDRM YWRDTNTGRL WLPNTPDPQK 61: PPRGFLAPPD ELNLTTASLP LLRWYEERFC FVLVTTAEFP RDPGQLLYIP KTYLLGRPPN 121: ASLPAPTTVE PTAQPPPSVA PLKGLLHNPA ASVLLRSRAW VTFSAVPDPE ALTFPRGDNV 181: ATASHPSGPR DTPPPRPPVG ARRHPTTELD ITHLHNASTT WLATRGLLRS PGRYVYFSPS 241: ASTWPVGIWT TGELVLGCDA ALVRARYGRE FMGLVISMHD SPPVEVMVVP AGQTLDRVGD 301: PADENPPGAL PGPPGGPRYR VFVLGSLTRA DNGSALDALR RVGGYPEEGT NYAQFLSRAY 361: AEFFSGDAGA EQGPRPPLFW RLTGLLATSG FAFVNAAHAN GAVCLSDLLG FLAHSRALAG 421: LAARGAAGCA ADSVFFNVSV LDPTARLQLE ARLQHLVAEI LEREQSLALH ALGYQLAFVL 481: DSPSAYDAVA PSAAHLIDAL YAEFLGGRVL TTPVVHRALF YASAVLRQPF LAGVPSAVQR 541: ERARRSLLIA SALCTSDVAA ATNADLRTAL ARADHQKTLF WLPDHFSPCA ASLRFDLDES 601: VFILDALAQA TRSETPVEVL AQQTHGLAST LTRWAHYNAL IRAFVPEASH RCGGQSANVE 661: PRILVPITHN ASYVVTHSPL PRGIGYKLTG VDVRRPLFLT YLTATCEGST RDIESKRLVR 721: TQNQRDLGLV GAVFMRYTPA GEVMSVLLVD TDNTQQQIAA GPTEGAPSVF SSDVPSTALL 781: LFPNGTVIHL LAFDTQPVAA IAPGFLAASA LGVVMITAAL AGILKVLRTS VPFFWRRE