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3.D.4.8.1
Cytochrome oxidase (Cox).  The factors limiting the allotopic production of the Cox2 subunit of yeast cytochrome c oxidase have been discovered (Nieto-Panqueva et al. 2024). The biogenesis pathway followed by the allotopically produced Cox2 subunit based on the participation of the 2 different structural/functional forms of the TIM23 translocon, TIM23MOTOR and TIM23SORT must follow a concerted and sequential mode of action to insert Cox2W56R into the inner mitochondrial membrane in the correct Nout-Cout topology (Nieto-Panqueva et al. 2024). The Plasmodium falciparum putative SURF1 protein can functionally replace SHY1, a COX assembly factor of complex IV of the mitochondrial electron transfer complex of Saccharomyces cerevisiae (Chellappan et al. 2021). 

Accession Number:P07255
Protein Name:Cytochrome c oxidase subunit 7A
Length:59
Molecular Weight:6963.00
Species:Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) [559292]
Number of TMSs:1
Location1 / Topology2 / Orientation3: Mitochondrion inner membrane1
Substrate

Cross database links:

DIP: DIP-5231N DIP-5231N
Entrez Gene ID: 851492   
KEGG: sce:YDL067C   

Gene Ontology

GO:0016021 C:integral to membrane
GO:0005751 C:mitochondrial respiratory chain complex IV
GO:0004129 F:cytochrome-c oxidase activity
GO:0006123 P:mitochondrial electron transport, cytochrome c to oxygen

References (8)

[1] “Characterization of COX9, the nuclear gene encoding the yeast mitochondrial protein cytochrome c oxidase subunit VIIa. Subunit VIIa lacks a leader peptide and is an essential component of the holoenzyme.”  Wright R.M.et.al.   3023385
[2] “Mitochondrial import of cytochrome c oxidase subunit VIIa in Saccharomyces cerevisiae. Identification of sequences required for mitochondrial localization in vivo.”  Duhl D.M.et.al.   2158998
[3] “Chromosomal localization and expression of CBS1, a translational activator of cytochrome b in yeast.”  Forsbach V.et.al.   2550765
[4] “The nucleotide sequence of Saccharomyces cerevisiae chromosome IV.”  Jacq C.et.al.   9169867
[5] “Approaching a complete repository of sequence-verified protein-encoding clones for Saccharomyces cerevisiae.”  Hu Y.et.al.   17322287
[6] “The nuclear-coded subunits of yeast cytochrome c oxidase. The amino acid sequences of subunits VII and VIIa, structural similarities between the three smallest polypeptides of the holoenzyme, and implications for biogenesis.”  Power S.D.et.al.   3013877
[7] “Kinetic properties and ligand binding of the eleven-subunit cytochrome-c oxidase from Saccharomyces cerevisiae isolated with a novel large-scale purification method.”  Geier B.M.et.al.   7851399
[8] “Global analysis of protein expression in yeast.”  Ghaemmaghami S.et.al.   14562106
Structure:
6GIQ   6HU9   6T0B   6T15   6YMX   6YMY     

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FASTA formatted sequence 
1:	MTIAPITGTI KRRVIMDIVL GFSLGGVMAS YWWWGFHMDK INKREKFYAE LAERKKQEN