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3.A.1.14.3
Iron (Fe3+)-hydroxamate (ferrichrome, coprogen, aerobactin, ferrioxamine B, schizakinen, rhodotorulic acid) porter, albomycin porter.  A FtsZ inhibitor can utilize siderophore-ferric iron uptake transporter systems, FepA, CirA (outer membrane transporters) and FhuBC (inner membrane transporter) for activity against Gram-negative bacterial pathogens (Bryan et al. 2024).

Accession Number:P07821
Protein Name:FhuC aka B0151
Length:265
Molecular Weight:28886.00
Species:Escherichia coli [83333]
Location1 / Topology2 / Orientation3: Cell inner membrane1 / Peripheral membrane protein2
Substrate iron(III) hydroxamate, elaiophylin

Cross database links:

RefSeq: AP_000812.1    NP_414693.1   
Entrez Gene ID: 945250   
Pfam: PF00005   
BioCyc: EcoCyc:FHUC-MONOMER    ECOL168927:B0151-MONOMER   
KEGG: ecj:JW0147    eco:b0151   

Gene Ontology

GO:0005886 C:plasma membrane
GO:0005524 F:ATP binding
GO:0015623 F:iron-chelate-transporting ATPase activity
GO:0005515 F:protein binding
GO:0006826 P:iron ion transport

References (6)

[1] “fhuC and fhuD genes for iron (III)-ferrichrome transport into Escherichia coli K-12.”  Coulton J.W.et.al.   3301821
[2] “Nucleotide sequence of the fhuC and fhuD genes involved in iron (III) hydroxamate transport: domains in FhuC homologous to ATP-binding proteins.”  Burkhardt R.et.al.   2823072
[3] “Systematic sequencing of the Escherichia coli genome: analysis of the 2.4-4.1 min (110,917-193,643 bp) region.”  Fujita N.et.al.   8202364
[4] “The complete genome sequence of Escherichia coli K-12.”  Blattner F.R.et.al.   9278503
[5] “Highly accurate genome sequences of Escherichia coli K-12 strains MG1655 and W3110.”  Hayashi K.et.al.   16738553
[6] “Iron(III) hydroxamate transport in Escherichia coli K-12: FhuB-mediated membrane association of the FhuC protein and negative complementation of fhuC mutants.”  Schultz-Hauser G.et.al.   1551849

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Predict TMSs (Predict number of transmembrane segments)
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FASTA formatted sequence 
1:	MQEYTNHSDT TFALRNISFR VPGRTLLHPL SLTFPAGKVT GLIGHNGSGK STLLKMLGRH 
61:	QPPSEGEILL DAQPLESWSS KAFARKVAYL PQQLPPAEGM TVRELVAIGR YPWHGALGRF 
121:	GAADREKVEE AISLVGLKPL AHRLVDSLSG GERQRAWIAM LVAQDSRCLL LDEPTSALDI 
181:	AHQVDVLSLV HRLSQERGLT VIAVLHDINM AARYCDYLVA LRGGEMIAQG TPAEIMRGET 
241:	LEMIYGIPMG ILPHPAGAAP VSFVY