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3.D.3.3.1
Ubiquinol:cytochrome c oxidoreductase.  The cytochrome bc1 complex resides in the inner membrane of mitochondria and transfers electrons from ubiquinol to cytochrome c. This electron transfer is coupled to the translocation of protons across the membrane by the protonmotive Q cycle mechanism. This mechanism topographically separates reduction of quinone and reoxidation of quinol at sites on opposite sites of the membrane, referred to as the center N (Qn site) and the center P (Qp site), respectively. Both are located on cytochrome b, a transmembrane protein of the bc1 complex that is encoded on the mitochondrial genome (Ding et al. 2006).

Accession Number:P08067
Protein Name:Cytochrome b-c1 complex subunit Rieske, mitochondrial
Length:215
Molecular Weight:23365.00
Species:Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) [559292]
Number of TMSs:1
Location1 / Topology2 / Orientation3: Mitochondrion1
Substrate hydron

Cross database links:

DIP: DIP-6616N DIP-6616N DIP-6616N DIP-6616N DIP-6616N DIP-6616N
Entrez Gene ID: 856689   
Pfam: PF00355    PF02921   
KEGG: sce:YEL024W    sce:YEL024W    sce:YEL024W    sce:YEL024W    sce:YEL024W   

Gene Ontology

GO:0005750 C:mitochondrial respiratory chain complex III
GO:0051537 F:2 iron, 2 sulfur cluster binding
GO:0046872 F:metal ion binding
GO:0008121 F:ubiquinol-cytochrome-c reductase activity
GO:0009060 P:aerobic respiration
GO:0006122 P:mitochondrial electron transport, ubiquinol to cytochrome c

References (40)

[1] “Isolation and characterization of the nuclear gene encoding the Rieske iron-sulfur protein (RIP1) from Saccharomyces cerevisiae.”  Beckmann J.D.et.al.   3036836
[2] “Mutational analysis of the mitochondrial Rieske iron-sulfur protein of Saccharomyces cerevisiae. I. Construction of a RIP1 deletion strain and isolation of temperature-sensitive mutants.”  Beckmann J.D.et.al.   2645276
[3] “The nucleotide sequence of Saccharomyces cerevisiae chromosome V.”  Dietrich F.S.et.al.   9169868
[4] “Approaching a complete repository of sequence-verified protein-encoding clones for Saccharomyces cerevisiae.”  Hu Y.et.al.   17322287
[5] “Mutational analysis of the mitochondrial Rieske iron-sulfur protein of Saccharomyces cerevisiae. III. Import, protease processing, and assembly into the cytochrome bc1 complex of iron-sulfur protein lacking the iron-sulfur cluster.”  Graham L.A.et.al.   1657998
[6] “Structure and function of the mitochondrial bc1 complex. A mutational analysis of the yeast Rieske iron-sulfur protein.”  Gatti D.L.et.al.   2538628
[7] “Structure at 2.3 A resolution of the cytochrome bc1 complex from the yeast Saccharomyces cerevisiae co-crystallized with an antibody Fv fragment.”  Hunte C.et.al.   10873857
[8] “Crystal structure of the yeast cytochrome bc1 complex with its bound substrate cytochrome c.”  Lange C.et.al.   11880631
[9] “Isolation and characterization of the nuclear gene encoding the Rieske iron-sulfur protein (RIP1) from Saccharomyces cerevisiae.”  Beckmann J.D.et.al.   3036836
[10] “Mutational analysis of the mitochondrial Rieske iron-sulfur protein of Saccharomyces cerevisiae. I. Construction of a RIP1 deletion strain and isolation of temperature-sensitive mutants.”  Beckmann J.D.et.al.   2645276
[11] “The nucleotide sequence of Saccharomyces cerevisiae chromosome V.”  Dietrich F.S.et.al.   9169868
[12] “Approaching a complete repository of sequence-verified protein-encoding clones for Saccharomyces cerevisiae.”  Hu Y.et.al.   17322287
[13] “Mutational analysis of the mitochondrial Rieske iron-sulfur protein of Saccharomyces cerevisiae. III. Import, protease processing, and assembly into the cytochrome bc1 complex of iron-sulfur protein lacking the iron-sulfur cluster.”  Graham L.A.et.al.   1657998
[14] “Structure and function of the mitochondrial bc1 complex. A mutational analysis of the yeast Rieske iron-sulfur protein.”  Gatti D.L.et.al.   2538628
[15] “Structure at 2.3 A resolution of the cytochrome bc1 complex from the yeast Saccharomyces cerevisiae co-crystallized with an antibody Fv fragment.”  Hunte C.et.al.   10873857
[16] “Crystal structure of the yeast cytochrome bc1 complex with its bound substrate cytochrome c.”  Lange C.et.al.   11880631
[17] “Isolation and characterization of the nuclear gene encoding the Rieske iron-sulfur protein (RIP1) from Saccharomyces cerevisiae.”  Beckmann J.D.et.al.   3036836
[18] “Mutational analysis of the mitochondrial Rieske iron-sulfur protein of Saccharomyces cerevisiae. I. Construction of a RIP1 deletion strain and isolation of temperature-sensitive mutants.”  Beckmann J.D.et.al.   2645276
[19] “The nucleotide sequence of Saccharomyces cerevisiae chromosome V.”  Dietrich F.S.et.al.   9169868
[20] “Approaching a complete repository of sequence-verified protein-encoding clones for Saccharomyces cerevisiae.”  Hu Y.et.al.   17322287
[21] “Mutational analysis of the mitochondrial Rieske iron-sulfur protein of Saccharomyces cerevisiae. III. Import, protease processing, and assembly into the cytochrome bc1 complex of iron-sulfur protein lacking the iron-sulfur cluster.”  Graham L.A.et.al.   1657998
[22] “Structure and function of the mitochondrial bc1 complex. A mutational analysis of the yeast Rieske iron-sulfur protein.”  Gatti D.L.et.al.   2538628
[23] “Structure at 2.3 A resolution of the cytochrome bc1 complex from the yeast Saccharomyces cerevisiae co-crystallized with an antibody Fv fragment.”  Hunte C.et.al.   10873857
[24] “Crystal structure of the yeast cytochrome bc1 complex with its bound substrate cytochrome c.”  Lange C.et.al.   11880631
[25] “Isolation and characterization of the nuclear gene encoding the Rieske iron-sulfur protein (RIP1) from Saccharomyces cerevisiae.”  Beckmann J.D.et.al.   3036836
[26] “Mutational analysis of the mitochondrial Rieske iron-sulfur protein of Saccharomyces cerevisiae. I. Construction of a RIP1 deletion strain and isolation of temperature-sensitive mutants.”  Beckmann J.D.et.al.   2645276
[27] “The nucleotide sequence of Saccharomyces cerevisiae chromosome V.”  Dietrich F.S.et.al.   9169868
[28] “Approaching a complete repository of sequence-verified protein-encoding clones for Saccharomyces cerevisiae.”  Hu Y.et.al.   17322287
[29] “Mutational analysis of the mitochondrial Rieske iron-sulfur protein of Saccharomyces cerevisiae. III. Import, protease processing, and assembly into the cytochrome bc1 complex of iron-sulfur protein lacking the iron-sulfur cluster.”  Graham L.A.et.al.   1657998
[30] “Structure and function of the mitochondrial bc1 complex. A mutational analysis of the yeast Rieske iron-sulfur protein.”  Gatti D.L.et.al.   2538628
[31] “Structure at 2.3 A resolution of the cytochrome bc1 complex from the yeast Saccharomyces cerevisiae co-crystallized with an antibody Fv fragment.”  Hunte C.et.al.   10873857
[32] “Crystal structure of the yeast cytochrome bc1 complex with its bound substrate cytochrome c.”  Lange C.et.al.   11880631
[33] “Isolation and characterization of the nuclear gene encoding the Rieske iron-sulfur protein (RIP1) from Saccharomyces cerevisiae.”  Beckmann J.D.et.al.   3036836
[34] “Mutational analysis of the mitochondrial Rieske iron-sulfur protein of Saccharomyces cerevisiae. I. Construction of a RIP1 deletion strain and isolation of temperature-sensitive mutants.”  Beckmann J.D.et.al.   2645276
[35] “The nucleotide sequence of Saccharomyces cerevisiae chromosome V.”  Dietrich F.S.et.al.   9169868
[36] “Approaching a complete repository of sequence-verified protein-encoding clones for Saccharomyces cerevisiae.”  Hu Y.et.al.   17322287
[37] “Mutational analysis of the mitochondrial Rieske iron-sulfur protein of Saccharomyces cerevisiae. III. Import, protease processing, and assembly into the cytochrome bc1 complex of iron-sulfur protein lacking the iron-sulfur cluster.”  Graham L.A.et.al.   1657998
[38] “Structure and function of the mitochondrial bc1 complex. A mutational analysis of the yeast Rieske iron-sulfur protein.”  Gatti D.L.et.al.   2538628
[39] “Structure at 2.3 A resolution of the cytochrome bc1 complex from the yeast Saccharomyces cerevisiae co-crystallized with an antibody Fv fragment.”  Hunte C.et.al.   10873857
[40] “Crystal structure of the yeast cytochrome bc1 complex with its bound substrate cytochrome c.”  Lange C.et.al.   11880631
Structure:
1EZV   1KB9   1KYO   1P84   2IBZ   3CX5   3CXH   4PD4   6GIQ   6HU9   [...more]

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Predict TMSs (Predict number of transmembrane segments)
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FASTA formatted sequence 
1:	MLGIRSSVKT CFKPMSLTSK RLISQSLLAS KSTYRTPNFD DVLKENNDAD KGRSYAYFMV 
61:	GAMGLLSSAG AKSTVETFIS SMTATADVLA MAKVEVNLAA IPLGKNVVVK WQGKPVFIRH 
121:	RTPHEIQEAN SVDMSALKDP QTDADRVKDP QWLIMLGICT HLGCVPIGEA GDFGGWFCPC 
181:	HGSHYDISGR IRKGPAPLNL EIPAYEFDGD KVIVG