| |
|---|---|
| Accession Number: | P08195 |
| Protein Name: | 4F2 cell-surface antigen heavy chain |
| Length: | 630 |
| Molecular Weight: | 67994.00 |
| Species: | Homo sapiens (Human) [9606] |
| Number of TMSs: | 2 |
| Location1 / Topology2 / Orientation3: | Apical cell membrane1 / Single-pass type II membrane protein2 |
| Substrate | cystine, glutamate(2-) |
Cross database links:
| RefSeq: | NP_001012679.1 NP_001012680.1 NP_001012681.1 NP_001012682.1 NP_001013269.1 NP_002385.3 |
|---|---|
| Entrez Gene ID: | 6520 |
| Pfam: | PF00128 |
| OMIM: |
158070 gene |
| BioCyc: | MetaCyc:MONOMER-15188 |
| KEGG: | hsa:6520 hsa:6520 |
Gene Ontology
GO:0016324
C:apical plasma membrane
GO:0009986
C:cell surface
GO:0016021
C:integral to membrane
GO:0042470
C:melanosome
GO:0005432
F:calcium:sodium antiporter activity
GO:0003824
F:catalytic activity
GO:0043169
F:cation binding
GO:0015175
F:neutral amino acid transmembrane transporte...
GO:0005515
F:protein binding
GO:0006816
P:calcium ion transport
GO:0005975
P:carbohydrate metabolic process
GO:0016049
P:cell growth
GO:0060356
P:leucine import
GO:0015827
P:tryptophan transport
GO:0005886
C:plasma membrane
GO:0015175
F:neutral amino acid transmembrane transporter activity
GO:0007596
P:blood coagulation
GO:0050900
P:leukocyte migration
| |
References (71)[1] “Molecular cloning of complementary DNAs encoding the heavy chain of the human 4F2 cell-surface antigen: a type II membrane glycoprotein involved in normal and neoplastic cell growth.” Quackenbush E.et.al. 3476959 [2] “Primary structure of the human 4F2 antigen heavy chain predicts a transmembrane protein with a cytoplasmic NH2 terminus.” Teixeira S.et.al. 3036867 [3] “Cloning, sequence analysis, and expression of the large subunit of the human lymphocyte activation antigen 4F2.” Lumadue J.A.et.al. 3480538 [4] “Isolation and structural characterization of the human 4F2 heavy-chain gene, an inducible gene involved in T-lymphocyte activation.” Gottesdiener K.M.et.al. 3265470 [5] “Human L-type amino acid transporter 1 (LAT1): characterization of function and expression in tumor cell lines.” Yanagida O.et.al. 11557028 [6] “Human chromosome 11 DNA sequence and analysis including novel gene identification.” Taylor T.D.et.al. 16554811 [7] “The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).” The MGC Project Teamet.al. 15489334 [8] “Identification and characterization of a membrane protein (y+L amino acid transporter-1) that associates with 4F2hc to encode the amino acid transport activity y+L. A candidate gene for lysinuric protein intolerance.” Torrents D.et.al. 9829974 [9] “Amino-acid transport by heterodimers of 4F2hc/CD98 and members of a permease family.” Mastroberardino L.et.al. 9751058 [10] “Amino acid transport of y+L-type by heterodimers of 4F2hc/CD98 and members of the glycoprotein-associated amino acid transporter family.” Pfeiffer R.et.al. 9878049 [11] “The heterodimeric amino acid transporter 4F2hc/y+LAT2 mediates arginine efflux in exchange with glutamine.” Broeer A.et.al. 10903140 [12] “Association of 4F2hc with light chains LAT1, LAT2 or y+LAT2 requires different domains.” Broeer A.et.al. 11311135 [13] “Role of the System L permease LAT1 in amino acid and iodothyronine transport in placenta.” Ritchie J.W.A.et.al. 11389679 [14] “Beta1 integrins show specific association with CD98 protein in low density membranes.” Kolesnikova T.V.et.al. 11696247 [15] “Thyroid hormone transport by the heterodimeric human system L amino acid transporter.” Friesema E.C.H.et.al. 11564694 [16] “Expression and regulation of 4F2hc and hLAT1 in human trophoblasts.” Okamoto Y.et.al. 11742812 [17] “Molecular cloning and characterization of CT120, a novel membrane-associated gene involved in amino acid transport and glutathione metabolism.” He X.H.et.al. 12270127 [18] “Transport of a neurotoxicant by molecular mimicry: the methylmercury-L-cysteine complex is a substrate for human L-type large neutral amino acid transporter (LAT) 1 and LAT2.” Simmons-Willis T.A.et.al. 12117417 [19] “Characterization of the system L amino acid transporter in T24 human bladder carcinoma cells.” Kim D.K.et.al. 12225859 [20] “Cluster analysis of an extensive human breast cancer cell line protein expression map database.” Harris R.A.et.al. 11840567 [21] “Nitric oxide synthesis requires activity of the cationic and neutral amino acid transport system y+L in human umbilical vein endothelium.” Arancibia-Garavilla Y.et.al. 14603368 [22] “CD98 and intracellular adhesion molecule I regulate the activity of amino acid transporter LAT-2 in polarized intestinal epithelia.” Liu X.et.al. 12716892 [23] “Identification and quantification of N-linked glycoproteins using hydrazide chemistry, stable isotope labeling and mass spectrometry.” Zhang H.et.al. 12754519 [24] “L-type amino acid transporter 1-mediated L-leucine transport at the inner blood-retinal barrier.” Tomi M.et.al. 15980244 [25] “Identification of stereoselective transporters for S-nitroso-L-cysteine: role of LAT1 and LAT2 in biological activity of S-nitrosothiols.” Li S.et.al. 15769744 [26] “Human plasma N-glycoproteome analysis by immunoaffinity subtraction, hydrazide chemistry, and mass spectrometry.” Liu T.et.al. 16335952 [27] “Global, in vivo, and site-specific phosphorylation dynamics in signaling networks.” Olsen J.V.et.al. 17081983 [28] “L-type amino acid transporter 1 as a potential molecular target in human astrocytic tumors.” Nawashiro H.et.al. 16496379 [29] “Proteomic and bioinformatic characterization of the biogenesis and function of melanosomes.” Chi A.et.al. 17081065 [30] “Quantitative analysis of global ubiquitination in HeLa cells by mass spectrometry.” Meierhofer D.et.al. 18781797 [31] “Ecto-phosphorylation of CD98 regulates cell-cell interactions.” Nguyen H.T.T.et.al. 19065266 [32] “Glycoproteomics analysis of human liver tissue by combination of multiple enzyme digestion and hydrazide chemistry.” Chen R.et.al. 19159218 [33] “Mass-spectrometric identification and relative quantification of N-linked cell surface glycoproteins.” Wollscheid B.et.al. 19349973 [34] “Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions.” Mayya V.et.al. 19690332 [35] “The structure of human 4F2hc ectodomain provides a model for homodimerization and electrostatic interaction with plasma membrane.” Fort J.et.al. 17724034 [36] “Molecular cloning of complementary DNAs encoding the heavy chain of the human 4F2 cell-surface antigen: a type II membrane glycoprotein involved in normal and neoplastic cell growth.” Quackenbush E.et.al. 3476959 [37] “Primary structure of the human 4F2 antigen heavy chain predicts a transmembrane protein with a cytoplasmic NH2 terminus.” Teixeira S.et.al. 3036867 [38] “Cloning, sequence analysis, and expression of the large subunit of the human lymphocyte activation antigen 4F2.” Lumadue J.A.et.al. 3480538 [39] “Isolation and structural characterization of the human 4F2 heavy-chain gene, an inducible gene involved in T-lymphocyte activation.” Gottesdiener K.M.et.al. 3265470 [40] “Human L-type amino acid transporter 1 (LAT1): characterization of function and expression in tumor cell lines.” Yanagida O.et.al. 11557028 [41] “Human chromosome 11 DNA sequence and analysis including novel gene identification.” Taylor T.D.et.al. 16554811 [42] “The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).” The MGC Project Teamet.al. 15489334 [43] “Identification and characterization of a membrane protein (y+L amino acid transporter-1) that associates with 4F2hc to encode the amino acid transport activity y+L. A candidate gene for lysinuric protein intolerance.” Torrents D.et.al. 9829974 [44] “Amino-acid transport by heterodimers of 4F2hc/CD98 and members of a permease family.” Mastroberardino L.et.al. 9751058 [45] “Amino acid transport of y+L-type by heterodimers of 4F2hc/CD98 and members of the glycoprotein-associated amino acid transporter family.” Pfeiffer R.et.al. 9878049 [46] “The heterodimeric amino acid transporter 4F2hc/y+LAT2 mediates arginine efflux in exchange with glutamine.” Broeer A.et.al. 10903140 [47] “Association of 4F2hc with light chains LAT1, LAT2 or y+LAT2 requires different domains.” Broeer A.et.al. 11311135 [48] “Role of the System L permease LAT1 in amino acid and iodothyronine transport in placenta.” Ritchie J.W.A.et.al. 11389679 [49] “Beta1 integrins show specific association with CD98 protein in low density membranes.” Kolesnikova T.V.et.al. 11696247 [50] “Thyroid hormone transport by the heterodimeric human system L amino acid transporter.” Friesema E.C.H.et.al. 11564694 [51] “Expression and regulation of 4F2hc and hLAT1 in human trophoblasts.” Okamoto Y.et.al. 11742812 [52] “Molecular cloning and characterization of CT120, a novel membrane-associated gene involved in amino acid transport and glutathione metabolism.” He X.H.et.al. 12270127 [53] “Transport of a neurotoxicant by molecular mimicry: the methylmercury-L-cysteine complex is a substrate for human L-type large neutral amino acid transporter (LAT) 1 and LAT2.” Simmons-Willis T.A.et.al. 12117417 [54] “Characterization of the system L amino acid transporter in T24 human bladder carcinoma cells.” Kim D.K.et.al. 12225859 [55] “Cluster analysis of an extensive human breast cancer cell line protein expression map database.” Harris R.A.et.al. 11840567 [56] “Nitric oxide synthesis requires activity of the cationic and neutral amino acid transport system y+L in human umbilical vein endothelium.” Arancibia-Garavilla Y.et.al. 14603368 [57] “CD98 and intracellular adhesion molecule I regulate the activity of amino acid transporter LAT-2 in polarized intestinal epithelia.” Liu X.et.al. 12716892 [58] “Identification and quantification of N-linked glycoproteins using hydrazide chemistry, stable isotope labeling and mass spectrometry.” Zhang H.et.al. 12754519 [59] “L-type amino acid transporter 1-mediated L-leucine transport at the inner blood-retinal barrier.” Tomi M.et.al. 15980244 [60] “Identification of stereoselective transporters for S-nitroso-L-cysteine: role of LAT1 and LAT2 in biological activity of S-nitrosothiols.” Li S.et.al. 15769744 [61] “Human plasma N-glycoproteome analysis by immunoaffinity subtraction, hydrazide chemistry, and mass spectrometry.” Liu T.et.al. 16335952 [62] “Global, in vivo, and site-specific phosphorylation dynamics in signaling networks.” Olsen J.V.et.al. 17081983 [63] “L-type amino acid transporter 1 as a potential molecular target in human astrocytic tumors.” Nawashiro H.et.al. 16496379 [64] “Proteomic and bioinformatic characterization of the biogenesis and function of melanosomes.” Chi A.et.al. 17081065 [65] “Quantitative analysis of global ubiquitination in HeLa cells by mass spectrometry.” Meierhofer D.et.al. 18781797 [66] “Ecto-phosphorylation of CD98 regulates cell-cell interactions.” Nguyen H.T.T.et.al. 19065266 [67] “Glycoproteomics analysis of human liver tissue by combination of multiple enzyme digestion and hydrazide chemistry.” Chen R.et.al. 19159218 [68] “Mass-spectrometric identification and relative quantification of N-linked cell surface glycoproteins.” Wollscheid B.et.al. 19349973 [69] “Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions.” Mayya V.et.al. 19690332 | |
| Structure: | |
External Searches:
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Analyze:
| Predict TMSs (Predict number of transmembrane segments) | ||||
| FASTA formatted sequence |
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1: MELQPPEASI AVVSIPRQLP GSHSEAGVQG LSAGDDSELG SHCVAQTGLE LLASGDPLPS 61: ASQNAEMIET GSDCVTQAGL QLLASSDPPA LASKNAEVTG TMSQDTEVDM KEVELNELEP 121: EKQPMNAASG AAMSLAGAEK NGLVKIKVAE DEAEAAAAAK FTGLSKEELL KVAGSPGWVR 181: TRWALLLLFW LGWLGMLAGA VVIIVRAPRC RELPAQKWWH TGALYRIGDL QAFQGHGAGN 241: LAGLKGRLDY LSSLKVKGLV LGPIHKNQKD DVAQTDLLQI DPNFGSKEDF DSLLQSAKKK 301: SIRVILDLTP NYRGENSWFS TQVDTVATKV KDALEFWLQA GVDGFQVRDI ENLKDASSFL 361: AEWQNITKGF SEDRLLIAGT NSSDLQQILS LLESNKDLLL TSSYLSDSGS TGEHTKSLVT 421: QYLNATGNRW CSWSLSQARL LTSFLPAQLL RLYQLMLFTL PGTPVFSYGD EIGLDAAALP 481: GQPMEAPVML WDESSFPDIP GAVSANMTVK GQSEDPGSLL SLFRRLSDQR SKERSLLHGD 541: FHAFSAGPGL FSYIRHWDQN ERFLVVLNFG DVGLSAGLQA SDLPASASLP AKADLLLSTQ 601: PGREEGSPLE LERLKLEPHE GLLLRFPYAA