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3.A.1.107.3
CcmABCD exporter; CcmD (69aas, 1TMS) is required for the release of CcmE (which binds heme in the periplasm) from CcmABC. CcmC (9.B.14.2.3) is required for the transfer of heme to CcmE in the periplasm (Richard-Fogal et al., 2008) In the presence of heme, CcmC and CcmE form a stable complex (Richard-Fogal & Kranz, 2010) as do CcmE and CcmF (San Francisco and Kranz 2014).

Accession Number:P0ABM0
Protein Name:CcmB
Length:220
Molecular Weight:23619.00
Species:Escherichia coli O157:H7 [83334]
Number of TMSs:6
Location1 / Topology2 / Orientation3: Cell inner membrane1 / Multi-pass membrane protein2
Substrate Heme

Cross database links:

RefSeq: NP_288780.1    NP_311116.1   
Entrez Gene ID: 916795    957177   
Pfam: PF03379   
BioCyc: ECOL83334:ECS3089-MONOMER   
KEGG: ece:Z3457    ecs:ECs3089   

Gene Ontology

GO:0016021 C:integral to membrane
GO:0005886 C:plasma membrane
GO:0015232 F:heme transporter activity
GO:0017004 P:cytochrome complex assembly
GO:0015886 P:heme transport

References (2)

[1] “Genome sequence of enterohaemorrhagic Escherichia coli O157:H7.”  Perna N.T.et.al.   11206551
[2] “Complete genome sequence of enterohemorrhagic Escherichia coli O157:H7 and genomic comparison with a laboratory strain K-12.”  Hayashi T.et.al.   11258796

External Searches:

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Predict TMSs (Predict number of transmembrane segments)
Window Size: Angle:  
FASTA formatted sequence 
1:	MMFWRIFRLE LRVAFRHSAE IANPLWFFLI VITLFPLSIG PEPQLLARIA PGIIWVAALL 
61:	SSLLALERLF RDDLQDGSLE QLMLLPLPLP AVVLAKVMAH WMVTGLPLLI LSPLVAMLLG 
121:	MDVYGWQVMA LTLLLGTPTL GFLGAPGVAL TVGLKRGGVL LSILVLPLTI PLLIFATAAM 
181:	DAASMHLPVD GYLAILGALL AGTATLSPFA TAAALRISIQ