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5.A.3.2.1 Anaerobic, respiratory, membrane-bound formate dehydrogenase, FdnGHI. Two protons are consumed in the cytoplasm while two protons are released in the periplasm, contributing to the pmf (Simon et al., 2008).
Accession Number:	P0AEK7
Protein Name:	FdnI aka B1476
Length:	217
Molecular Weight:	25368.00
Species:	Escherichia coli [83333]
Number of TMSs:	4
Location¹ / Topology² / Orientation³:	Cell inner membrane¹ / Multi-pass membrane protein²
Substrate	electron

Structure:
RefSeq:	AP_002099.1 NP_415993.1
Entrez Gene ID:	946038
Pfam:	PF00033
BioCyc:	EcoCyc:FDNI-MONOMER ECOL168927:B1476-MONOMER MetaCyc:FDNI-MONOMER
KEGG:	ecj:JW1472 eco:b1476
Gene Ontology GO:0009326 C:formate dehydrogenase complex GO:0016021 C:integral to membrane GO:0005886 C:plasma membrane GO:0009055 F:electron carrier activity GO:0008863 F:formate dehydrogenase activity GO:0046872 F:metal ion binding GO:0009061 P:anaerobic respiration GO:0017004 P:cytochrome complex assembly GO:0022904 P:respiratory electron transport chain GO:0006810 P:transport
References (6) [1] “Nitrate-inducible formate dehydrogenase in Escherichia coli K-12. I. Nucleotide sequence of the fdnGHI operon and evidence that opal (UGA) encodes selenocysteine.” Berg B.L.et.al. 1834669 [2] “A 570-kb DNA sequence of the Escherichia coli K-12 genome corresponding to the 28.0-40.1 min region on the linkage map.” Aiba H.et.al. 9097039 [3] “The complete genome sequence of Escherichia coli K-12.” Blattner F.R.et.al. 9278503 [4] “Highly accurate genome sequences of Escherichia coli K-12 strains MG1655 and W3110.” Hayashi K.et.al. 16738553 [5] “Global topology analysis of the Escherichia coli inner membrane proteome.” Daley D.O.et.al. 15919996 [6] “Molecular basis of proton motive force generation: structure of formate dehydrogenase-N.” Jormakka M.et.al. 11884747
1KQF 1KQG

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FASTA formatted sequence

1:	MSKSKMIVRT KFIDRACHWT VVICFFLVAL SGISFFFPTL QWLTQTFGTP QMGRILHPFF 
61:	GIAIFVALMF MFVRFVHHNI PDKKDIPWLL NIVEVLKGNE HKVADVGKYN AGQKMMFWSI 
121:	MSMIFVLLVT GVIIWRPYFA QYFPMQVVRY SLLIHAAAGI ILIHAILIHM YMAFWVKGSI 
181:	KGMIEGKVSR RWAKKHHPRW YREIEKAEAK KESEEGI

5.A.3.2.1
Anaerobic, respiratory, membrane-bound formate dehydrogenase, FdnGHI. Two protons are consumed in the cytoplasm while two protons are released in the periplasm, contributing to the pmf (Simon et al., 2008).

Cross database links:

Gene Ontology

References (6)

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5.A.3.2.1Anaerobic, respiratory, membrane-bound formate dehydrogenase, FdnGHI. Two protons are consumed in the cytoplasm while two protons are released in the periplasm, contributing to the pmf (Simon et al., 2008).

Cross database links:

Gene Ontology

References (6)

External Searches:

Analyze:

5.A.3.2.1
Anaerobic, respiratory, membrane-bound formate dehydrogenase, FdnGHI. Two protons are consumed in the cytoplasm while two protons are released in the periplasm, contributing to the pmf (Simon et al., 2008).