9.A.8.1.1
Ferrous iron uptake system, FeoAB. FeoB is the main transporter while
FeoC is a transcriptional regulator. FeoA has a Src-Homology (SH3)
domain (a β-barrel with two overlying α-helices) plus two extra α-helices
not usually found in SH3 domains. FeoA interacts with the
cytoplasmic domain of the conserved core portion of the FeoB
transmembrane region, but may not function as a GTPase activator as
previously proposed (Lau et al. 2012). FeoB transports Fe(II) from the periplasm to the cytoplasm, but the C-terminal domain can also bind Mn2+ and Zn2+ as well (Orzel et al. 2023).
|
| Accession Number: | P0AEL3 |
|---|
| Protein Name: | Ferrous iron transport protein A |
|---|
| Length: | 75 |
|---|
| Molecular Weight: | 8371.00 |
|---|
| Species: | Escherichia coli (strain K12) [83333] |
|---|
| Substrate |
iron(2+), zinc(2+), manganese(2+) |
|---|
1: MQYTPDTAWK ITGFSREISP AYRQKLLSLG MLPGSSFNVV RVAPLGDPIH IETRRVSLVL
61: RKKDLALLEV EAVSC