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3.A.1.5.3
Nickel porter. Histidine 416 of NikA is essential for nickel uptake (Cavazza et al., 2011).

Accession Number:P0AFA9
Protein Name:Nickel transport system permease protein NikC aka B3478
Length:277
Molecular Weight:30362.00
Species:Escherichia coli [83333]
Number of TMSs:5
Location1 / Topology2 / Orientation3: Cell inner membrane1 / Multi-pass membrane protein2
Substrate nickel(2+)

Cross database links:

DIP: DIP-48065N
RefSeq: AP_004314.1    NP_417935.1   
Entrez Gene ID: 947990   
Pfam: PF00528   
BioCyc: EcoCyc:NIKC-MONOMER    ECOL168927:B3478-MONOMER   
KEGG: ecj:JW3443    eco:b3478   

Gene Ontology

GO:0016021 C:integral to membrane
GO:0005886 C:plasma membrane
GO:0005215 F:transporter activity
GO:0015675 P:nickel ion transport

References (5)

[1] “The nik operon of Escherichia coli encodes a periplasmic binding-protein-dependent transport system for nickel.”  Navarro C.et.al.   7934931
[2] “Analysis of the Escherichia coli genome. V. DNA sequence of the region from 76.0 to 81.5 minutes.”  Sofia H.J.et.al.   8041620
[3] “The complete genome sequence of Escherichia coli K-12.”  Blattner F.R.et.al.   9278503
[4] “Highly accurate genome sequences of Escherichia coli K-12 strains MG1655 and W3110.”  Hayashi K.et.al.   16738553
[5] “Global topology analysis of the Escherichia coli inner membrane proteome.”  Daley D.O.et.al.   15919996

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Predict TMSs (Predict number of transmembrane segments)
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FASTA formatted sequence 
1:	MNFFLSSRWS VRLALIIIAL LALIALTSQW WLPYDPQAID LPSRLLSPDA QHWLGTDHLG 
61:	RDIFSRLMAA TRVSLGSVMA CLLLVLTLGL VIGGSAGLIG GRVDQATMRV ADMFMTFPTS 
121:	ILSFFMVGVL GTGLTNVIIA IALSHWAWYA RMVRSLVISL RQREFVLASR LSGAGHVRVF 
181:	VDHLAGAVIP SLLVLATLDI GHMMLHVAGM SFLGLGVTAP TAEWGVMIND ARQYIWTQPL 
241:	QMFWPGLALF ISVMAFNLVG DALRDHLDPH LVTEHAH