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3.D.1.1.1 NADH dehydrogenase I, NuoA-N. NuoL probably comprises part of the proton pathway (Nakamaru-Ogiso et al. 2010). NuoL (ND5), NuoM (ND4) and NuoN (ND2) are all homologous to proton:sodium antiporters and may all play reoles in pumping protons using a similar mechanism (Sato et al. 2013).
Accession Number:	P0AFC3
Protein Name:	NUOA aka B2288
Length:	147
Molecular Weight:	16457.00
Species:	Escherichia coli [83333]
Number of TMSs:	3
Location¹ / Topology² / Orientation³:	Cell inner membrane¹ / Multi-pass membrane protein²
Substrate	hydron

Structure:
RefSeq:	AP_002886.1 NP_416791.3
Entrez Gene ID:	946764
Pfam:	PF00507
BioCyc:	EcoCyc:NUOA-MONOMER ECOL168927:B2288-MONOMER MetaCyc:NUOA-MONOMER
KEGG:	ecj:JW2283 eco:b2288
Gene Ontology GO:0016021 C:integral to membrane GO:0045272 C:plasma membrane respiratory chain complex I GO:0008137 F:NADH dehydrogenase (ubiquinone) activity GO:0015453 F:oxidoreduction-driven active transmembrane ... GO:0048038 F:quinone binding GO:0009061 P:anaerobic respiration GO:0055114 P:oxidation reduction GO:0019684 P:photosynthesis, light reaction GO:0006810 P:transport
References (5) [1] “The gene locus of the proton-translocating NADH: ubiquinone oxidoreductase in Escherichia coli. Organization of the 14 genes and relationship between the derived proteins and subunits of mitochondrial complex I.” Weidner U.et.al. 7690854 [2] “Construction of a contiguous 874-kb sequence of the Escherichia coli-K12 genome corresponding to 50.0-68.8 min on the linkage map and analysis of its sequence features.” Yamamoto Y.et.al. 9205837 [3] “The complete genome sequence of Escherichia coli K-12.” Blattner F.R.et.al. 9278503 [4] “Highly accurate genome sequences of Escherichia coli K-12 strains MG1655 and W3110.” Hayashi K.et.al. 16738553 [5] “Global topology analysis of the Escherichia coli inner membrane proteome.” Daley D.O.et.al. 15919996
3rko

UniProt (Universal Protein Resource)
CDD Search (Conserved Domain Database)

Predict TMSs (Predict number of transmembrane segments)

FASTA formatted sequence

1:	MSMSTSTEVI AHHWAFAIFL IVAIGLCCLM LVGGWFLGGR ARARSKNVPF ESGIDSVGSA 
61:	RLRLSAKFYL VAMFFVIFDV EALYLFAWST SIRESGWVGF VEAAIFIFVL LAGLVYLVRI 
121:	GALDWTPARS RRERMNPETN SIANRQR

3.D.1.1.1
NADH dehydrogenase I, NuoA-N. NuoL probably comprises part of the proton pathway (Nakamaru-Ogiso et al. 2010). NuoL (ND5), NuoM (ND4) and NuoN (ND2) are all homologous to proton:sodium antiporters and may all play reoles in pumping protons using a similar mechanism (Sato et al. 2013).

Cross database links:

Gene Ontology

References (5)

External Searches:

Analyze:

3.D.1.1.1NADH dehydrogenase I, NuoA-N. NuoL probably comprises part of the proton pathway (Nakamaru-Ogiso et al. 2010). NuoL (ND5), NuoM (ND4) and NuoN (ND2) are all homologous to proton:sodium antiporters and may all play reoles in pumping protons using a similar mechanism (Sato et al. 2013).

Cross database links:

Gene Ontology

References (5)

External Searches:

Analyze:

3.D.1.1.1
NADH dehydrogenase I, NuoA-N. NuoL probably comprises part of the proton pathway (Nakamaru-Ogiso et al. 2010). NuoL (ND5), NuoM (ND4) and NuoN (ND2) are all homologous to proton:sodium antiporters and may all play reoles in pumping protons using a similar mechanism (Sato et al. 2013).