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3.D.1.1.1 NADH dehydrogenase I, NuoA-N. NuoL probably comprises part of the proton pathway (Nakamaru-Ogiso et al. 2010). NuoL (ND5), NuoM (ND4) and NuoN (ND2) are all homologous to proton:sodium antiporters and may all play reoles in pumping protons using a similar mechanism (Sato et al. 2013).
Accession Number:	P0AFD1
Protein Name:	NUOE aka B2285
Length:	166
Molecular Weight:	18590.00
Species:	Escherichia coli [83333]
Number of TMSs:	1
Location¹ / Topology² / Orientation³:	Cell inner membrane¹ / Peripheral membrane protein² / Cytoplasmic side³
Substrate	hydron

DIP:	DIP-35917N
RefSeq:	AP_002883.1 NP_416788.1
Entrez Gene ID:	946746
Pfam:	PF01257
BioCyc:	EcoCyc:NUOE-MONOMER ECOL168927:B2285-MONOMER MetaCyc:NUOE-MONOMER
KEGG:	ecj:JW2280 eco:b2285
Gene Ontology GO:0045272 C:plasma membrane respiratory chain complex I GO:0051537 F:2 iron, 2 sulfur cluster binding GO:0046872 F:metal ion binding GO:0051287 F:NAD or NADH binding GO:0050136 F:NADH dehydrogenase (quinone) activity GO:0015453 F:oxidoreduction-driven active transmembrane ... GO:0048038 F:quinone binding GO:0009061 P:anaerobic respiration GO:0055114 P:oxidation reduction
References (6) [1] “The gene locus of the proton-translocating NADH: ubiquinone oxidoreductase in Escherichia coli. Organization of the 14 genes and relationship between the derived proteins and subunits of mitochondrial complex I.” Weidner U.et.al. 7690854 [2] “Mutations in NADH:ubiquinone oxidoreductase of Escherichia coli affect growth on mixed amino acids.” Pruss B.M.et.al. 8157582 [3] “Construction of a contiguous 874-kb sequence of the Escherichia coli-K12 genome corresponding to 50.0-68.8 min on the linkage map and analysis of its sequence features.” Yamamoto Y.et.al. 9205837 [4] “The complete genome sequence of Escherichia coli K-12.” Blattner F.R.et.al. 9278503 [5] “Highly accurate genome sequences of Escherichia coli K-12 strains MG1655 and W3110.” Hayashi K.et.al. 16738553 [6] “Isolation and characterization of the proton-translocating NADH: ubiquinone oxidoreductase from Escherichia coli.” Leif H.et.al. 7607227

UniProt (Universal Protein Resource)
CDD Search (Conserved Domain Database)

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FASTA formatted sequence

1:	MHENQQPQTE AFELSAAERE AIEHEMHHYE DPRAASIEAL KIVQKQRGWV PDGAIHAIAD 
61:	VLGIPASDVE GVATFYSQIF RQPVGRHVIR YCDSVVCHIN GYQGIQAALE KKLNIKPGQT 
121:	TFDGRFTLLP TCCLGNCDKG PNMMIDEDTH AHLTPEAIPE LLERYK

3.D.1.1.1
NADH dehydrogenase I, NuoA-N. NuoL probably comprises part of the proton pathway (Nakamaru-Ogiso et al. 2010). NuoL (ND5), NuoM (ND4) and NuoN (ND2) are all homologous to proton:sodium antiporters and may all play reoles in pumping protons using a similar mechanism (Sato et al. 2013).

Cross database links:

Gene Ontology

References (6)

External Searches:

Analyze:

3.D.1.1.1NADH dehydrogenase I, NuoA-N. NuoL probably comprises part of the proton pathway (Nakamaru-Ogiso et al. 2010). NuoL (ND5), NuoM (ND4) and NuoN (ND2) are all homologous to proton:sodium antiporters and may all play reoles in pumping protons using a similar mechanism (Sato et al. 2013).

Cross database links:

Gene Ontology

References (6)

External Searches:

Analyze:

3.D.1.1.1
NADH dehydrogenase I, NuoA-N. NuoL probably comprises part of the proton pathway (Nakamaru-Ogiso et al. 2010). NuoL (ND5), NuoM (ND4) and NuoN (ND2) are all homologous to proton:sodium antiporters and may all play reoles in pumping protons using a similar mechanism (Sato et al. 2013).