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3.D.1.1.1 NADH dehydrogenase I, NuoA-N. NuoL probably comprises part of the proton pathway (Nakamaru-Ogiso et al. 2010). NuoL (ND5), NuoM (ND4) and NuoN (ND2) are all homologous to proton:sodium antiporters and may all play reoles in pumping protons using a similar mechanism (Sato et al. 2013).
Accession Number:	P0AFE8
Protein Name:	NUOM aka B2277
Length:	509
Molecular Weight:	56525.00
Species:	Escherichia coli [83333]
Number of TMSs:	14
Location¹ / Topology² / Orientation³:	Cell inner membrane¹ / Multi-pass membrane protein²
Substrate	hydron

Structure:
RefSeq:	AP_002875.1 NP_416780.1
Entrez Gene ID:	947731
Pfam:	PF00361
BioCyc:	EcoCyc:NUOM-MONOMER ECOL168927:B2277-MONOMER MetaCyc:NUOM-MONOMER
KEGG:	ecj:JW2272 eco:b2277
Gene Ontology GO:0005887 C:integral to plasma membrane GO:0045272 C:plasma membrane respiratory chain complex I GO:0008137 F:NADH dehydrogenase (ubiquinone) activity GO:0015453 F:oxidoreduction-driven active transmembrane ... GO:0048039 F:ubiquinone binding GO:0009060 P:aerobic respiration GO:0009061 P:anaerobic respiration GO:0042773 P:ATP synthesis coupled electron transport GO:0015990 P:electron transport coupled proton transport
References (6) [1] “The gene locus of the proton-translocating NADH: ubiquinone oxidoreductase in Escherichia coli. Organization of the 14 genes and relationship between the derived proteins and subunits of mitochondrial complex I.” Weidner U.et.al. 7690854 [2] “Escherichia coli mutants lacking NADH dehydrogenase I have a competitive disadvantage in stationary phase.” Zambrano M.M.et.al. 8366049 [3] “Construction of a contiguous 874-kb sequence of the Escherichia coli-K12 genome corresponding to 50.0-68.8 min on the linkage map and analysis of its sequence features.” Yamamoto Y.et.al. 9205837 [4] “The complete genome sequence of Escherichia coli K-12.” Blattner F.R.et.al. 9278503 [5] “Highly accurate genome sequences of Escherichia coli K-12 strains MG1655 and W3110.” Hayashi K.et.al. 16738553 [6] “Global topology analysis of the Escherichia coli inner membrane proteome.” Daley D.O.et.al. 15919996
3rko

UniProt (Universal Protein Resource)
CDD Search (Conserved Domain Database)

Predict TMSs (Predict number of transmembrane segments)

FASTA formatted sequence

1:	MLLPWLILIP FIGGFLCWQT ERFGVKVPRW IALITMGLTL ALSLQLWLQG GYSLTQSAGI 
61:	PQWQSEFDMP WIPRFGISIH LAIDGLSLLM VVLTGLLGVL AVLCSWKEIE KYQGFFHLNL 
121:	MWILGGVIGV FLAIDMFLFF FFWEMMLVPM YFLIALWGHK ASDGKTRITA ATKFFIYTQA 
181:	SGLVMLIAIL ALVFVHYNAT GVWTFNYEEL LNTPMSSGVE YLLMLGFFIA FAVKMPVVPL 
241:	HGWLPDAHSQ APTAGSVDLA GILLKTAAYG LLRFSLPLFP NASAEFAPIA MWLGVIGIFY 
301:	GAWMAFAQTD IKRLIAYTSV SHMGFVLIAI YTGSQLAYQG AVIQMIAHGL SAAGLFILCG 
361:	QLYERIHTRD MRMMGGLWSK MKWLPALSLF FAVATLGMPG TGNFVGEFMI LFGSFQVVPV 
421:	ITVISTFGLV FASVYSLAML HRAYFGKAKS QIASQELPGM SLRELFMILL LVVLLVLLGF 
481:	YPQPILDTSH SAIGNIQQWF VNSVTTTRP

3.D.1.1.1
NADH dehydrogenase I, NuoA-N. NuoL probably comprises part of the proton pathway (Nakamaru-Ogiso et al. 2010). NuoL (ND5), NuoM (ND4) and NuoN (ND2) are all homologous to proton:sodium antiporters and may all play reoles in pumping protons using a similar mechanism (Sato et al. 2013).

Cross database links:

Gene Ontology

References (6)

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3.D.1.1.1NADH dehydrogenase I, NuoA-N. NuoL probably comprises part of the proton pathway (Nakamaru-Ogiso et al. 2010). NuoL (ND5), NuoM (ND4) and NuoN (ND2) are all homologous to proton:sodium antiporters and may all play reoles in pumping protons using a similar mechanism (Sato et al. 2013).

Cross database links:

Gene Ontology

References (6)

External Searches:

Analyze:

3.D.1.1.1
NADH dehydrogenase I, NuoA-N. NuoL probably comprises part of the proton pathway (Nakamaru-Ogiso et al. 2010). NuoL (ND5), NuoM (ND4) and NuoN (ND2) are all homologous to proton:sodium antiporters and may all play reoles in pumping protons using a similar mechanism (Sato et al. 2013).