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3.A.1.2.8 Autoinducer-2 (AI-2, a furanosyl borate diester: (3aS,6S,6aR)-2,2,6,6a-tetrahydroxy-3a-methyltetrahydrofuro[3,2-d][1,3,2]dioxaborolan-2-uide) uptake porter (Taga et al., 2001, 2003)
Accession Number:	P0AFS1
Protein Name:	LsrD(M)AKA Inner membrane ABC transporter permease protein ydeZ
Length:	330
Molecular Weight:	34456.00
Species:	Escherichia coli [83333]
Number of TMSs:	10
Location¹ / Topology² / Orientation³:	Cell inner membrane¹ / Multi-pass membrane protein²
Substrate

RefSeq:	AP_002136.1 NP_416032.1
Entrez Gene ID:	946264
Pfam:	PF02653
BioCyc:	EcoCyc:YDEZ-MONOMER ECOL168927:B1515-MONOMER
KEGG:	ecj:JW1508 eco:b1515
Gene Ontology GO:0016021 C:integral to membrane GO:0005886 C:plasma membrane GO:0005215 F:transporter activity GO:0006810 P:transport
References (6) [1] “A 570-kb DNA sequence of the Escherichia coli K-12 genome corresponding to the 28.0-40.1 min region on the linkage map.” Aiba H.et.al. 9097039 [2] “The complete genome sequence of Escherichia coli K-12.” Blattner F.R.et.al. 9278503 [3] “Highly accurate genome sequences of Escherichia coli K-12 strains MG1655 and W3110.” Hayashi K.et.al. 16738553 [4] “Regulation of uptake and processing of the quorum-sensing autoinducer AI-2 in Escherichia coli.” Xavier K.B.et.al. 15601708 [5] “Cyclic AMP (cAMP) and cAMP receptor protein influence both synthesis and uptake of extracellular autoinducer 2 in Escherichia coli.” Wang L.et.al. 15743955 [6] “Global topology analysis of the Escherichia coli inner membrane proteome.” Daley D.O.et.al. 15919996

UniProt (Universal Protein Resource)
CDD Search (Conserved Domain Database)

Predict TMSs (Predict number of transmembrane segments)

FASTA formatted sequence

1:	MRIRYGWELA LAALLVIEIV AFGAINPRML DLNMLLFSTS DFICIGIVAL PLTMVIVSGG 
61:	IDISFGSTIG LCAIALGVLF QSGVPMPLAI LLTLLLGALC GLINAGLIIY TKVNPLVITL 
121:	GTLYLFAGSA LLLSGMAGAT GYEGIGGFPM AFTDFANLDV LGLPVPLIIF LICLLVFWLW 
181:	LHKTHAGRNV FLIGQSPRVA LYSAIPVNRT LCALYAMTGL ASAVAAVLLV SYFGSARSDL 
241:	GASFLMPAIT AVVLGGANIY GGSGSIIGTA IAVLLVGYLQ QGLQMAGVPN QVSSALSGAL 
301:	LIVVVVGRSV SLHRQQIKEW LARRANNPLP

3.A.1.2.8
Autoinducer-2 (AI-2, a furanosyl borate diester: (3aS,6S,6aR)-2,2,6,6a-tetrahydroxy-3a-methyltetrahydrofuro[3,2-d][1,3,2]dioxaborolan-2-uide) uptake porter (Taga et al., 2001, 2003)

Cross database links:

Gene Ontology

References (6)

External Searches:

Analyze:

3.A.1.2.8Autoinducer-2 (AI-2, a furanosyl borate diester: (3aS,6S,6aR)-2,2,6,6a-tetrahydroxy-3a-methyltetrahydrofuro[3,2-d][1,3,2]dioxaborolan-2-uide) uptake porter (Taga et al., 2001, 2003)

Cross database links:

Gene Ontology

References (6)

External Searches:

Analyze:

3.A.1.2.8
Autoinducer-2 (AI-2, a furanosyl borate diester: (3aS,6S,6aR)-2,2,6,6a-tetrahydroxy-3a-methyltetrahydrofuro[3,2-d][1,3,2]dioxaborolan-2-uide) uptake porter (Taga et al., 2001, 2003)