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2.A.38.1.1
K+ uptake transporter (K+:H+ symporter), TrkHA. The 3-d structure of TrkH is known (Cao et al. 2011).  Molecular dynamics simulations of TrkH have been reported (Domene and Furini, 2012).  TrkA, which forms a tertameric ring that needs to bind ATP to activate transport, interacts with the Enzyme IIANtr of the PTS (TC# 4.A) which inhibits transport (Lee et al. 2007).

Accession Number:P0AFZ7
Protein Name:Trk system potassium uptake protein TrkH aka B3849
Length:483
Molecular Weight:52960.00
Species:Escherichia coli [83333]
Number of TMSs:11
Location1 / Topology2 / Orientation3: Cell inner membrane1 / Multi-pass membrane protein2
Substrate potassium(1+)

Cross database links:

DIP: DIP-47978N
RefSeq: AP_003953.1    YP_026273.1   
Entrez Gene ID: 948333   
Pfam: PF02386   
BioCyc: EcoCyc:TRKH-MONOMER   
KEGG: ecj:JW5576    eco:b3849   

Gene Ontology

GO:0016021 C:integral to membrane
GO:0005886 C:plasma membrane
GO:0008324 F:cation transmembrane transporter activity
GO:0006813 P:potassium ion transport
GO:0055085 P:transmembrane transport

References (7)

[1] “Nucleotide sequence between the fadB gene and the rrnA operon from Escherichia coli.”  Nakahigashi K.et.al.   2243799
[2] “TrkH and its homolog, TrkG, determine the specificity and kinetics of cation transport by the Trk system of Escherichia coli.”  Schlosser A.et.al.   7896723
[3] “Analysis of the Escherichia coli genome: DNA sequence of the region from 84.5 to 86.5 minutes.”  Daniels D.L.et.al.   1379743
[4] “The complete genome sequence of Escherichia coli K-12.”  Blattner F.R.et.al.   9278503
[5] “Escherichia coli K-12: a cooperatively developed annotation snapshot -- 2005.”  Riley M.et.al.   16397293
[6] “Highly accurate genome sequences of Escherichia coli K-12 strains MG1655 and W3110.”  Hayashi K.et.al.   16738553
[7] “Global topology analysis of the Escherichia coli inner membrane proteome.”  Daley D.O.et.al.   15919996

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Predict TMSs (Predict number of transmembrane segments)
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FASTA formatted sequence 
1:	MHFRAITRIV GLLVILFSGT MIIPGLVALI YRDGAGRAFT QTFFVALAIG SMLWWPNRKE 
61:	KGELKSREGF LIVVLFWTVL GSVGALPFIF SESPNLTITD AFFESFSGLT TTGATTLVGL 
121:	DSLPHAILFY RQMLQWFGGM GIIVLAVAIL PILGVGGMQL YRAEMPGPLK DNKMRPRIAE 
181:	TAKTLWLIYV LLTVACALAL WFAGMDAFDA IGHSFATIAI GGFSTHDASI GYFDSPTINT 
241:	IIAIFLLISG CNYGLHFSLL SGRSLKVYWR DPEFRMFIGV QFTLVVICTL VLWFHNVYSS 
301:	ALMTINQAFF QVVSMATTAG FTTDSIARWP LFLPVLLLCS AFIGGCAGST GGGLKVIRIL 
361:	LLFKQGNREL KRLVHPNAVY SIKLGNRALP ERILEAVWGF FSAYALVFIV SMLAIIATGV 
421:	DDFSAFASVV ATLNNLGPGL GVVADNFTSM NPVAKWILIA NMLFGRLEVF TLLVLFTPTF 
481:	WRE