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3.A.2.2.5
H -translocating V-type ATPase (Dettmer et al., 2006). The mung bean (Phaseolus aureus) subunits a and c (c' and c") alone catalyzes passive channel-mediated proton flux, but the a,c,d complex does not (Ouyang et al., 2008).  A 4 TMS c-subunit of Tamarix hispida (onion), almost identical to the c-subunit of the A. thaliana homologue, plays a stress tolerance role in response to salt, drought, UV, oxidation, heat, cold, and heavy metals (Gao et al. 2011). The VHA-H subunit is up-regluated upon high salt stress conditions (Yang et al. 2018). The VHAc`1 protein seems to play an important role in plant stress tolerance (Wang et al. 2020).

Accession Number:P0CAN7
Protein Name:V-type proton ATPase subunit E3
Length:237
Molecular Weight:27085.00
Species:Arabidopsis thaliana (Mouse-ear cress) [3702]
Location1 / Topology2 / Orientation3: Vacuole membrane1 / Peripheral membrane protein2
Substrate hydron

Cross database links:

Entrez Gene ID: 842725   
Pfam: PF01991   
KEGG: ath:AT1G64200   

Gene Ontology

GO:0005886 C:plasma membrane
GO:0033178 C:proton-transporting two-sector ATPase complex, catalytic domain
GO:0005774 C:vacuolar membrane
GO:0046961 F:proton-transporting ATPase activity, rotational mechanism
GO:0015986 P:ATP synthesis coupled proton transport

References (4)

[1] “Sequence and analysis of chromosome 1 of the plant Arabidopsis thaliana.”  Theologis A.et.al.   11130712
[2] “Small cysteine-rich peptides resembling antimicrobial peptides have been under-predicted in plants.”  Silverstein K.A.T.et.al.   17565583
[3] “A simple nomenclature for a complex proton pump: VHA genes encode the vacuolar H(+)-ATPase.”  Sze H.et.al.   11950611
[4] “Arabidopsis vacuolar H(+)-ATPase subunit E isoform 1 is required for Golgi organization and vacuole function in embryogenesis.”  Strompen G.et.al.   15610355

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Predict TMSs (Predict number of transmembrane segments)
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FASTA formatted sequence 
1:	MNDADASIQI QQMVRFIRQE AEEKANEISI SSEEEFNIEK LQLVEAEKKK IRQEYEKKEK 
61:	QVDVRKKIDY SMQLNASRIK VLQAQDDIVN AMKEEAAKQL LKVSQHGFFN HHHHQYKHLL 
121:	KDLIVQCLLR LKEPAVLLRC REEDLDIVES MLDDASEEYC KKAKVHAPEI IVDKDIFLPP 
181:	APSDDDPHAL SCAGGVVLAS RDGKIVCENT LDARLEVAFR NKLPEIRKSL FGKVGAA